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Exercise-induced asthma: critical analysis of the protective role of montelukast

Exercise-induced asthma/exercise-induced bronchospasm (EIA/EIB) is a prevalent and clinically important disease affecting young children through older adulthood. These terms are often used interchangeably and the differences are not clearly defined in the literature. The pathogenesis of EIA/EIB may...

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Detalles Bibliográficos
Autor principal: Carver, Terrence W
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048606/
https://www.ncbi.nlm.nih.gov/pubmed/21437147
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author Carver, Terrence W
author_facet Carver, Terrence W
author_sort Carver, Terrence W
collection PubMed
description Exercise-induced asthma/exercise-induced bronchospasm (EIA/EIB) is a prevalent and clinically important disease affecting young children through older adulthood. These terms are often used interchangeably and the differences are not clearly defined in the literature. The pathogenesis of EIA/EIB may be different in those with persistent asthma compared to those with exercise-induced symptoms only. The natural history of EIA is unclear and may be different for elite athletes. Leukotriene biology has helped the understanding of EIB. The type and intensity of exercise are important factors for EIB. Exercise participation is necessary for proper development and control of EIA is recommended. Symptoms of EIB should be confirmed by proper testing. Biologic markers may also be helpful in diagnosis. Not all exercise symptoms are from EIB. Many medication and nonpharmacologic treatments are available. Asthma education is an important component of managing EIA. Many medications have been tested and the comparisons are complicated. Montelukast is a US Food and Drug Administration-approved asthma and EIB controller and has a number of potential advantages to other asthma medications including short onset of action, ease of use, and lack of tolerance. Not all patients improve with montelukast and rescue medication should be available.
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spelling pubmed-30486062011-03-23 Exercise-induced asthma: critical analysis of the protective role of montelukast Carver, Terrence W J Asthma Allergy Review Exercise-induced asthma/exercise-induced bronchospasm (EIA/EIB) is a prevalent and clinically important disease affecting young children through older adulthood. These terms are often used interchangeably and the differences are not clearly defined in the literature. The pathogenesis of EIA/EIB may be different in those with persistent asthma compared to those with exercise-induced symptoms only. The natural history of EIA is unclear and may be different for elite athletes. Leukotriene biology has helped the understanding of EIB. The type and intensity of exercise are important factors for EIB. Exercise participation is necessary for proper development and control of EIA is recommended. Symptoms of EIB should be confirmed by proper testing. Biologic markers may also be helpful in diagnosis. Not all exercise symptoms are from EIB. Many medication and nonpharmacologic treatments are available. Asthma education is an important component of managing EIA. Many medications have been tested and the comparisons are complicated. Montelukast is a US Food and Drug Administration-approved asthma and EIB controller and has a number of potential advantages to other asthma medications including short onset of action, ease of use, and lack of tolerance. Not all patients improve with montelukast and rescue medication should be available. Dove Medical Press 2009-10-22 /pmc/articles/PMC3048606/ /pubmed/21437147 Text en © 2009 Carver, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Carver, Terrence W
Exercise-induced asthma: critical analysis of the protective role of montelukast
title Exercise-induced asthma: critical analysis of the protective role of montelukast
title_full Exercise-induced asthma: critical analysis of the protective role of montelukast
title_fullStr Exercise-induced asthma: critical analysis of the protective role of montelukast
title_full_unstemmed Exercise-induced asthma: critical analysis of the protective role of montelukast
title_short Exercise-induced asthma: critical analysis of the protective role of montelukast
title_sort exercise-induced asthma: critical analysis of the protective role of montelukast
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048606/
https://www.ncbi.nlm.nih.gov/pubmed/21437147
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