Reconstruction is not renovation – the role of remodeling in asthma

The chronicity of asthma results not only in persistent lung inflammation but also in changes in structure and composition of this vital organ. These changes are most commonly referred to as remodeling, and include epithelial dysplasia, angiogenesis, changes in the extracellular matrix and increased...

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Detalles Bibliográficos
Autores principales: Weckmann, Markus, Trian, Thomas, Oliver, Brian GG
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048608/
https://www.ncbi.nlm.nih.gov/pubmed/21437142
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author Weckmann, Markus
Trian, Thomas
Oliver, Brian GG
author_facet Weckmann, Markus
Trian, Thomas
Oliver, Brian GG
author_sort Weckmann, Markus
collection PubMed
description The chronicity of asthma results not only in persistent lung inflammation but also in changes in structure and composition of this vital organ. These changes are most commonly referred to as remodeling, and include epithelial dysplasia, angiogenesis, changes in the extracellular matrix and increased smooth muscle mass. In this review we summarize recent findings on the contribution of remodeling to the pathological phenotype of asthma. We discuss how and why current treatment (such as corticosteroids) options fail to adequately treat remodeling.
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spelling pubmed-30486082011-03-23 Reconstruction is not renovation – the role of remodeling in asthma Weckmann, Markus Trian, Thomas Oliver, Brian GG J Asthma Allergy Review The chronicity of asthma results not only in persistent lung inflammation but also in changes in structure and composition of this vital organ. These changes are most commonly referred to as remodeling, and include epithelial dysplasia, angiogenesis, changes in the extracellular matrix and increased smooth muscle mass. In this review we summarize recent findings on the contribution of remodeling to the pathological phenotype of asthma. We discuss how and why current treatment (such as corticosteroids) options fail to adequately treat remodeling. Dove Medical Press 2009-03-16 /pmc/articles/PMC3048608/ /pubmed/21437142 Text en © 2009 Weckmann et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Weckmann, Markus
Trian, Thomas
Oliver, Brian GG
Reconstruction is not renovation – the role of remodeling in asthma
title Reconstruction is not renovation – the role of remodeling in asthma
title_full Reconstruction is not renovation – the role of remodeling in asthma
title_fullStr Reconstruction is not renovation – the role of remodeling in asthma
title_full_unstemmed Reconstruction is not renovation – the role of remodeling in asthma
title_short Reconstruction is not renovation – the role of remodeling in asthma
title_sort reconstruction is not renovation – the role of remodeling in asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048608/
https://www.ncbi.nlm.nih.gov/pubmed/21437142
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AT trianthomas reconstructionisnotrenovationtheroleofremodelinginasthma
AT oliverbriangg reconstructionisnotrenovationtheroleofremodelinginasthma

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