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Omalizumab in the management of patients with allergic (IgE-mediated) asthma
Immunoglobulin E (IgE) is central to the pathophysiology of allergic asthma. Omalizumab, an anti-IgE monoclonal antibody, binds to the FcɛRI binding site on free IgE. As a result, circulating free IgE is reduced, IgE is prevented from attaching to mast cells and basophils, and FcɛRI receptor express...
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| Formato: | Texto |
| Lenguaje: | English |
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Dove Medical Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048609/ https://www.ncbi.nlm.nih.gov/pubmed/21437144 |