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The Regulatory Subunit of PKA-I Remains Partially Structured and Undergoes β-Aggregation upon Thermal Denaturation

BACKGROUND: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of...

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Detalles Bibliográficos
Autores principales:	Dao, Khanh K., Pey, Angel L., Gjerde, Anja Underhaug, Teigen, Knut, Byeon, In-Ja L., Døskeland, Stein O., Gronenborn, Angela M., Martinez, Aurora
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048872/ https://www.ncbi.nlm.nih.gov/pubmed/21394209 http://dx.doi.org/10.1371/journal.pone.0017602

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