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MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors

MYC and phosphoinositide 3-kinase (PI3K)-pathway deregulation are common in human prostate cancer. Through examination of 194 human prostate tumors, we observed statistically significant co-occurrence of MYC amplification and PI3K-pathway alteration, raising the possibility that these two lesions co...

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Detalles Bibliográficos
Autores principales:	Clegg, Nicola J., Couto, Suzana S., Wongvipat, John, Hieronymus, Haley, Carver, Brett S., Taylor, Barry S., Ellwood-Yen, Katharine, Gerald, William L., Sander, Chris, Sawyers, Charles L.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048873/ https://www.ncbi.nlm.nih.gov/pubmed/21394210 http://dx.doi.org/10.1371/journal.pone.0017449

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