Cargando…

Interleukin-6 Induces Gr-1+CD11b+ Myeloid Cells to Suppress CD8+ T Cell-Mediated Liver Injury in Mice

BACKGROUND: Agonist antibodies against CD137 (4–1BB) on T lymphocytes are used to increase host anti-tumor immunity, but often leading to severe liver injury in treated mice or in patients during clinical trials. Interleukin-6 (IL-6) has been reported to protect hepatocyte death, but the role of IL-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Liang, Wang, Jun, Li, Xiaozhu, Xing, Qiao, Du, Peishuang, Su, Lishan, Wang, Shengdian
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048877/ https://www.ncbi.nlm.nih.gov/pubmed/21394214 http://dx.doi.org/10.1371/journal.pone.0017631

Ejemplares similares

Interferon regulatory factor-8 modulates the development of tumour-induced CD11b(+)Gr-1(+) myeloid cells
por: Stewart, Trina J, et al.
Publicado: (2009)

CD24–p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages
por: Li, Dongling, et al.
Publicado: (2018)

Gr-1(+)CD11b(+) Myeloid-Derived Suppressor Cells: Formidable Partners in Tumor Metastasis
por: Yang, Li, et al.
Publicado: (2010)

Gr1(int)CD11b(+) Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
por: Obregón-Henao, Andrés, et al.
Publicado: (2013)

NAD(+) attenuates experimental autoimmune encephalomyelitis through induction of CD11b(+) gr-1(+) myeloid-derived suppressor cells
por: Wang, Jin-Li, et al.
Publicado: (2020)

Gr1(−/low)CD11b(−/low)MHCII(+) myeloid cells boost T cell anti‐tumor efficacy
por: Payne, Kyle K., et al.
Publicado: (2018)

Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11b(+)Gr-1(+) Myeloid-derived Suppressor Cells
por: Lee, Jung-Mi, et al.
Publicado: (2010)

Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells
por: Zhuang, Junling, et al.
Publicado: (2012)

Novel CD11b(+)Gr-1(+)Sca-1(+) myeloid cells drive mortality in bacterial infection
por: Park, Min Young, et al.
Publicado: (2020)

Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
por: Ding, Ying, et al.
Publicado: (2018)

Ovarian cancer modulates the immunosuppressive function of CD11b(+)Gr1(+) myeloid cells via glutamine metabolism
por: Udumula, Mary P., et al.
Publicado: (2021)

Interleukin-27 Gene Therapy Prevents the Development of Autoimmune Encephalomyelitis but Fails to Attenuate Established Inflammation due to the Expansion of CD11b(+)Gr-1(+) Myeloid Cells
por: Zhu, Jianmin, et al.
Publicado: (2018)

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b(+)Gr-1(+) myeloid cells without compromising CD8(+) T cell immune responses
por: Rubinstein, Mark P, et al.
Publicado: (2013)

Gr-1(+)CD11b(+) Immature Myeloid Cells (IMC) Promote Resistance of Pro-Inflammatory T Cells to Suppression by Regulatory T Cells in Atherosclerotic Apo E- Deficient Mice
por: Chen, Yulin, et al.
Publicado: (2014)

Ultraviolet Light B-Mediated Inhibition of Skin Catalase Activity Promotes Gr-1(+)CD11b(+) Myeloid Cell Expansion
por: Sullivan, Nicholas J., et al.
Publicado: (2011)

Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11b(high)/Gr1(high) myeloid cells
por: Iwai, Toshiki, et al.
Publicado: (2018)

SOCS3 Suppression Promoted the Recruitment of CD11b(+)Gr-1(−)F4/80(−)MHCII(−) Early-Stage Myeloid-Derived Suppressor Cells and Accelerated Interleukin-6-Related Tumor Invasion via Affecting Myeloid Differentiation in Breast Cancer
por: Zhang, Wenwen, et al.
Publicado: (2018)

CD45(+)CD33(low)CD11b(dim) myeloid-derived suppressor cells suppress CD8(+) T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer
por: Mao, Fang-yuan, et al.
Publicado: (2018)

Increase of Circulating CD11b(+)Gr1(+) cells and Recruitment into the Synovium in Osteoarthritic Mice with Hyperlipidemia
por: Uchida, Kentaro, et al.
Publicado: (2013)

Gr-1+CD11b+ myeloid cells efficiently home to site of injury after intravenous administration and enhance diabetic wound healing by neoangiogenesis
por: Tong, Xiaozhe, et al.
Publicado: (2014)

Hydrogen Sulfide Attenuates the Recruitment of CD11b(+)Gr-1(+) Myeloid Cells and Regulates Bax/Bcl-2 Signaling in Myocardial Ischemia Injury
por: Zhang, Youen, et al.
Publicado: (2014)

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells
por: Gallego-Ortega, David, et al.
Publicado: (2015)

Presence of Infected Gr-1(int)CD11b(hi)CD11c(int) Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice
por: Abdissa, Ketema, et al.
Publicado: (2018)

CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment
por: Zhang, Qian-Qian, et al.
Publicado: (2015)

Novel adherent CD11b(+) Gr-1(+) tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment
por: Tsubaki, Takuya, et al.
Publicado: (2018)

Recruitment of bone marrow CD11b(+)Gr-1(+) cells by polymeric nanoparticles for antigen cross-presentation
por: Yang, Ya-Wun, et al.
Publicado: (2017)

Neonatal microbial colonization in mice promotes prolonged dominance of CD11b(+)Gr-1(+) cells and accelerated establishment of the CD4(+) T cell population in the spleen
por: Kristensen, Matilde B, et al.
Publicado: (2015)

TLR4/MyD88-Induced CD11b(+)Gr-1(int)F4/80(+) Non-Migratory Myeloid Cells Suppress Th2 Effector Function in the Lung
por: Arora, Meenakshi, et al.
Publicado: (2010)

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
por: Delano, Matthew J., et al.
Publicado: (2007)

Identification and characterization of B220(+)/B220(−) subpopulations in murine Gr1(+)CD11b(+) cells during tumorigenesis
por: Zhang, Zhiqian, et al.
Publicado: (2021)

Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation and suppresses cell proliferation in human monocytic leukemia cells
por: Fang, Jianwu, et al.
Publicado: (2017)

Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells
por: Chen, Rongyi, et al.
Publicado: (2014)

Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity
por: Lee, Younghee, et al.
Publicado: (2019)

Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4(+)CD25(+) Regulatory T Cells
por: Wang, Da-Wei, et al.
Publicado: (2016)

miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhibit tumor metastasis through improved host immunity
por: Ishii, Hiroki, et al.
Publicado: (2018)

CD11c(+)CD88(+)CD317(+) myeloid cells are critical mediators of persistent CNS autoimmunity
por: Manouchehri, Navid, et al.
Publicado: (2021)

Cd11c(+)B220(+)Gr-1(+) Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells
por: Nakano, Hideki, et al.
Publicado: (2001)

Immune suppression of vaccine-induced CD8(+) T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4(+) T cells
por: Podschwadt, Philip, et al.
Publicado: (2022)

Murine gammaherpesvirus-68 expands, but does not activate, CD11b(+) gr-1(+) splenocytes in vivo
por: Nelson, Daniel A, et al.
Publicado: (2012)

Interleukin-7 regulates CD127 expression and promotes CD8(+) T cell activity in patients with primary cutaneous melanoma
por: He, Hongxia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gigtnoeuacr5nfg9o4727fl5l6