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Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation

Solitary tracheobronchial papilloma (STBP) is a rare benign tumor that primarily involves the tracheobronchial tree. Human papilloma virus (HPV) infection is associated with dysplasia and a high risk of carcinoma in these lesions. The cytomorphology of STBP is not well established in the literature....

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Autores principales: Lang, Tee U., Khalbuss, Walid E., Monaco, Sara E., Pantanowitz, Liron
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049241/
https://www.ncbi.nlm.nih.gov/pubmed/21383960
http://dx.doi.org/10.4103/1742-6413.77286
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author Lang, Tee U.
Khalbuss, Walid E.
Monaco, Sara E.
Pantanowitz, Liron
author_facet Lang, Tee U.
Khalbuss, Walid E.
Monaco, Sara E.
Pantanowitz, Liron
author_sort Lang, Tee U.
collection PubMed
description Solitary tracheobronchial papilloma (STBP) is a rare benign tumor that primarily involves the tracheobronchial tree. Human papilloma virus (HPV) infection is associated with dysplasia and a high risk of carcinoma in these lesions. The cytomorphology of STBP is not well established in the literature. Our aim is to characterize the cytomorphologic features of STBP, with histologic correlation in a series of 6 patients — 4 males and 2 females — with a mean age of 67 years (range, 53-88 years). There were 5 biopsy-proven squamous papillomas and 1 glandular papilloma. On surgical biopsy, squamous papillomas exhibited cytological atypia (4 graded mild and 1 graded moderate with focal severe dysplasia), surface erosion, and inflammation. Cytology specimens available for review included a combination of 4 fine-needle aspirations (FNAs), 2 bronchoalveolar lavages and 2 (of 3) bronchial brushings. Cytologic findings associated with squamous papillomas included atypical squamous cells and rare squamous cell resembling koilocyte in 1 bronchial brushing. Sheets of squamous cells were identified in another specimen. Several cases had a prominent background of acute inflammation, and candida was present in 1 specimen. HPV in-situ hybridization was positive in 1 case and negative in 2 cases. A p16 immunocytochemical stain performed on 1 cell block was negative. In conclusion, although STBP is a rare neoplasm, these cases may be encountered in respiratory cytology samples. FNA of papillomas yields fewer lesional cells compared to exfoliative samples. These lesions may be mistaken in cytology specimens for squamous cell carcinoma, squamous-lined cavitary lesions, an infectious (fungal) process, reactive squamous metaplasia, or oral contamination.
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spelling pubmed-30492412011-03-07 Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation Lang, Tee U. Khalbuss, Walid E. Monaco, Sara E. Pantanowitz, Liron Cytojournal Original Article Solitary tracheobronchial papilloma (STBP) is a rare benign tumor that primarily involves the tracheobronchial tree. Human papilloma virus (HPV) infection is associated with dysplasia and a high risk of carcinoma in these lesions. The cytomorphology of STBP is not well established in the literature. Our aim is to characterize the cytomorphologic features of STBP, with histologic correlation in a series of 6 patients — 4 males and 2 females — with a mean age of 67 years (range, 53-88 years). There were 5 biopsy-proven squamous papillomas and 1 glandular papilloma. On surgical biopsy, squamous papillomas exhibited cytological atypia (4 graded mild and 1 graded moderate with focal severe dysplasia), surface erosion, and inflammation. Cytology specimens available for review included a combination of 4 fine-needle aspirations (FNAs), 2 bronchoalveolar lavages and 2 (of 3) bronchial brushings. Cytologic findings associated with squamous papillomas included atypical squamous cells and rare squamous cell resembling koilocyte in 1 bronchial brushing. Sheets of squamous cells were identified in another specimen. Several cases had a prominent background of acute inflammation, and candida was present in 1 specimen. HPV in-situ hybridization was positive in 1 case and negative in 2 cases. A p16 immunocytochemical stain performed on 1 cell block was negative. In conclusion, although STBP is a rare neoplasm, these cases may be encountered in respiratory cytology samples. FNA of papillomas yields fewer lesional cells compared to exfoliative samples. These lesions may be mistaken in cytology specimens for squamous cell carcinoma, squamous-lined cavitary lesions, an infectious (fungal) process, reactive squamous metaplasia, or oral contamination. Medknow Publications & Media Pvt Ltd 2011-03-03 /pmc/articles/PMC3049241/ /pubmed/21383960 http://dx.doi.org/10.4103/1742-6413.77286 Text en © 2011 Lang, et al.; licensee Cytopathology Foundation Inc. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lang, Tee U.
Khalbuss, Walid E.
Monaco, Sara E.
Pantanowitz, Liron
Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation
title Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation
title_full Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation
title_fullStr Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation
title_full_unstemmed Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation
title_short Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation
title_sort solitary tracheobronchial papilloma: cytomorphology and ancillary studies with histologic correlation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049241/
https://www.ncbi.nlm.nih.gov/pubmed/21383960
http://dx.doi.org/10.4103/1742-6413.77286
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