An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells

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Epstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects and immortalizes primary human B cells in vitro into indefinitely proliferating lymphoblastoid cell lines, which represent a model for EBV-induced tumorigenesis. The immortalization efficiency is very low sugg...

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Detalles Bibliográficos
Autores principales: Nikitin, Pavel A., Yan, Christopher M., Forte, Eleonora, Bocedi, Alessio, Tourigny, Jason P., White, Robert E., Allday, Martin J., Patel, Amee, Dave, Sandeep S., Kim, William, Hu, Katherine, Guo, Jing, Tainter, David, Rusyn, Elena, Luftig, Micah A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049316/
https://www.ncbi.nlm.nih.gov/pubmed/21147465
http://dx.doi.org/10.1016/j.chom.2010.11.004
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