Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

The naturally occurring antagonist of interleukin-1, IL-1RA, is highly neuroprotective experimentally, shows few adverse effects, and inhibits the systemic acute phase response to stroke. A single regime pilot study showed slow penetration into cerebrospinal fluid (CSF) at experimentally therapeutic...

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Detalles Bibliográficos
Autores principales: Galea, James, Ogungbenro, Kayode, Hulme, Sharon, Greenhalgh, Andrew, Aarons, Leon, Scarth, Sylvia, Hutchinson, Peter, Grainger, Samantha, King, Andrew, Hopkins, Stephen J, Rothwell, Nancy, Tyrrell, Pippa
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049499/
https://www.ncbi.nlm.nih.gov/pubmed/20628399
http://dx.doi.org/10.1038/jcbfm.2010.103

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