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Endothelial function in a cardiovascular risk population with borderline ankle–brachial index

INTRODUCTION: The diagnosis of peripheral arterial disease (PAD) can be made by measuring the ankle–brachial index (ABI). Traditionally ABI values > 1.00–1.40 have been considered normal and ABI ≤ 0.90 defines PAD. Recent studies, however, have shown that individuals with ABI values between 0.90–...

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Autores principales: Syvänen, Kari, Korhonen, Päivi, Partanen, Auli, Aarnio, Pertti
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049545/
https://www.ncbi.nlm.nih.gov/pubmed/21415923
http://dx.doi.org/10.2147/VHRM.S17249
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author Syvänen, Kari
Korhonen, Päivi
Partanen, Auli
Aarnio, Pertti
author_facet Syvänen, Kari
Korhonen, Päivi
Partanen, Auli
Aarnio, Pertti
author_sort Syvänen, Kari
collection PubMed
description INTRODUCTION: The diagnosis of peripheral arterial disease (PAD) can be made by measuring the ankle–brachial index (ABI). Traditionally ABI values > 1.00–1.40 have been considered normal and ABI ≤ 0.90 defines PAD. Recent studies, however, have shown that individuals with ABI values between 0.90–1.00 are also at risk of cardiovascular events. We studied this cardiovascular risk population subgroup in order to determine their endothelial function using peripheral arterial tonometry (PAT). METHODS: We selected 66 individuals with cardiovascular risk and borderline ABI. They all had hypertension, newly diagnosed glucose disorder, metabolic syndrome, obesity, or a ten year risk of cardiovascular disease death of 5% or more according to the Systematic Coronary Risk Evaluation System (SCORE). Subjects with previously diagnosed diabetes or cardiovascular disease were excluded. Endothelial function was assessed by measuring the reactive hyperemia index (RHI) from fingertips using an Endo-PAT device. RESULTS: The mean ABI was 0.95 and mean RHI 2.11. Endothelial dysfunction, defined as RHI < 1.67, was detected in 15/66 (23%) of the subjects. There were no statistically significant differences in RHI values between subjects with different cardiovascular risk factors. The only exception was that subjects with impaired fasting glucose (IFG) had slightly lower RHI values (mean RHI 1.91) than subjects without IFG (mean RHI 2.24) (P = 0.02). CONCLUSIONS: In a cardiovascular risk population with borderline ABI nearly every fourth subject had endothelial dysfunction, indicating an elevated risk of cardiovascular events. This might point out a subgroup of individuals in need of more aggressive treatment for their risk factors.
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spelling pubmed-30495452011-03-17 Endothelial function in a cardiovascular risk population with borderline ankle–brachial index Syvänen, Kari Korhonen, Päivi Partanen, Auli Aarnio, Pertti Vasc Health Risk Manag Original Research INTRODUCTION: The diagnosis of peripheral arterial disease (PAD) can be made by measuring the ankle–brachial index (ABI). Traditionally ABI values > 1.00–1.40 have been considered normal and ABI ≤ 0.90 defines PAD. Recent studies, however, have shown that individuals with ABI values between 0.90–1.00 are also at risk of cardiovascular events. We studied this cardiovascular risk population subgroup in order to determine their endothelial function using peripheral arterial tonometry (PAT). METHODS: We selected 66 individuals with cardiovascular risk and borderline ABI. They all had hypertension, newly diagnosed glucose disorder, metabolic syndrome, obesity, or a ten year risk of cardiovascular disease death of 5% or more according to the Systematic Coronary Risk Evaluation System (SCORE). Subjects with previously diagnosed diabetes or cardiovascular disease were excluded. Endothelial function was assessed by measuring the reactive hyperemia index (RHI) from fingertips using an Endo-PAT device. RESULTS: The mean ABI was 0.95 and mean RHI 2.11. Endothelial dysfunction, defined as RHI < 1.67, was detected in 15/66 (23%) of the subjects. There were no statistically significant differences in RHI values between subjects with different cardiovascular risk factors. The only exception was that subjects with impaired fasting glucose (IFG) had slightly lower RHI values (mean RHI 1.91) than subjects without IFG (mean RHI 2.24) (P = 0.02). CONCLUSIONS: In a cardiovascular risk population with borderline ABI nearly every fourth subject had endothelial dysfunction, indicating an elevated risk of cardiovascular events. This might point out a subgroup of individuals in need of more aggressive treatment for their risk factors. Dove Medical Press 2011 2011-02-23 /pmc/articles/PMC3049545/ /pubmed/21415923 http://dx.doi.org/10.2147/VHRM.S17249 Text en © 2011 Syvänen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Syvänen, Kari
Korhonen, Päivi
Partanen, Auli
Aarnio, Pertti
Endothelial function in a cardiovascular risk population with borderline ankle–brachial index
title Endothelial function in a cardiovascular risk population with borderline ankle–brachial index
title_full Endothelial function in a cardiovascular risk population with borderline ankle–brachial index
title_fullStr Endothelial function in a cardiovascular risk population with borderline ankle–brachial index
title_full_unstemmed Endothelial function in a cardiovascular risk population with borderline ankle–brachial index
title_short Endothelial function in a cardiovascular risk population with borderline ankle–brachial index
title_sort endothelial function in a cardiovascular risk population with borderline ankle–brachial index
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049545/
https://www.ncbi.nlm.nih.gov/pubmed/21415923
http://dx.doi.org/10.2147/VHRM.S17249
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