Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

EGFR and c-Met are both overexpressed in lung cancer and initiate similar downstream signaling, which may be redundant. To determine how frequently ligands that initiate signaling of both pathways are found in lung cancer, we analyzed serum for hepatocyte growth factor (HGF), transforming growth fac...

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Detalles Bibliográficos
Autores principales: Stabile, Laura P., Rothstein, Mary E., Keohavong, Phouthone, Lenzner, Diana, Land, Stephanie R., Gaither-Davis, Autumn L., Kim, K. Jin, Kaminski, Naftali, Siegfried, Jill M.
Formato: Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049550/
https://www.ncbi.nlm.nih.gov/pubmed/21390244
http://dx.doi.org/10.3390/cancers2042153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049550/
https://www.ncbi.nlm.nih.gov/pubmed/21390244
http://dx.doi.org/10.3390/cancers2042153

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