Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

BACKGROUND: Infant leukaemia is likely initiated in utero. METHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression....

Descripción completa

Detalles Bibliográficos
Autores principales: Ognjanovic, S, Blair, C, Spector, L G, Robison, L L, Roesler, M, Ross, J A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049556/
https://www.ncbi.nlm.nih.gov/pubmed/21157452
http://dx.doi.org/10.1038/sj.bjc.6606046
Descripción
Sumario:BACKGROUND: Infant leukaemia is likely initiated in utero. METHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. RESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37–0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. CONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

Ejemplares similares