Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

BACKGROUND: Infant leukaemia is likely initiated in utero. METHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression....

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Autores principales: Ognjanovic, S, Blair, C, Spector, L G, Robison, L L, Roesler, M, Ross, J A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049556/
https://www.ncbi.nlm.nih.gov/pubmed/21157452
http://dx.doi.org/10.1038/sj.bjc.6606046
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author Ognjanovic, S
Blair, C
Spector, L G
Robison, L L
Roesler, M
Ross, J A
author_facet Ognjanovic, S
Blair, C
Spector, L G
Robison, L L
Roesler, M
Ross, J A
author_sort Ognjanovic, S
collection PubMed
description BACKGROUND: Infant leukaemia is likely initiated in utero. METHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. RESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37–0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. CONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.
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spelling pubmed-30495562012-02-01 Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study Ognjanovic, S Blair, C Spector, L G Robison, L L Roesler, M Ross, J A Br J Cancer Epidemiology BACKGROUND: Infant leukaemia is likely initiated in utero. METHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. RESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37–0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. CONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia. Nature Publishing Group 2011-02-01 2010-12-14 /pmc/articles/PMC3049556/ /pubmed/21157452 http://dx.doi.org/10.1038/sj.bjc.6606046 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Ognjanovic, S
Blair, C
Spector, L G
Robison, L L
Roesler, M
Ross, J A
Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study
title Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study
title_full Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study
title_fullStr Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study
title_full_unstemmed Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study
title_short Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study
title_sort analgesic use during pregnancy and risk of infant leukaemia: a children's oncology group study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049556/
https://www.ncbi.nlm.nih.gov/pubmed/21157452
http://dx.doi.org/10.1038/sj.bjc.6606046
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