Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins

BACKGROUND: A positive association between socio-economic position and breast cancer has been widely observed, but not hitherto within twin pairs, where shared familial factors were adjusted for. METHODS: We used data on education and other factors from the Danish Twin Registry, The Danish Cancer Re...

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Autores principales: Madsen, M, Andersen, P K, Gerster, M, Nybo Andersen, A-M, Christensen, K, Osler, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049577/
https://www.ncbi.nlm.nih.gov/pubmed/21285973
http://dx.doi.org/10.1038/sj.bjc.6606090
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author Madsen, M
Andersen, P K
Gerster, M
Nybo Andersen, A-M
Christensen, K
Osler, M
author_facet Madsen, M
Andersen, P K
Gerster, M
Nybo Andersen, A-M
Christensen, K
Osler, M
author_sort Madsen, M
collection PubMed
description BACKGROUND: A positive association between socio-economic position and breast cancer has been widely observed, but not hitherto within twin pairs, where shared familial factors were adjusted for. METHODS: We used data on education and other factors from the Danish Twin Registry, The Danish Cancer Registry, and official registers on a total of 16 310 twins. Unpaired and intrapair Cox regression analyses were compared. RESULTS: In the unpaired analysis, an educational gradient in breast cancer risk was found. Similar results were seen in the intrapair analyses of all twins, although no longer statistically significant. When intrapair analyses were stratified on zygosity, the effect of education was attenuated in the monozygotic twins. CONCLUSION: The main findings support an effect of education beyond shared familial factors.
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spelling pubmed-30495772012-02-01 Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins Madsen, M Andersen, P K Gerster, M Nybo Andersen, A-M Christensen, K Osler, M Br J Cancer Short Communication BACKGROUND: A positive association between socio-economic position and breast cancer has been widely observed, but not hitherto within twin pairs, where shared familial factors were adjusted for. METHODS: We used data on education and other factors from the Danish Twin Registry, The Danish Cancer Registry, and official registers on a total of 16 310 twins. Unpaired and intrapair Cox regression analyses were compared. RESULTS: In the unpaired analysis, an educational gradient in breast cancer risk was found. Similar results were seen in the intrapair analyses of all twins, although no longer statistically significant. When intrapair analyses were stratified on zygosity, the effect of education was attenuated in the monozygotic twins. CONCLUSION: The main findings support an effect of education beyond shared familial factors. Nature Publishing Group 2011-02-01 2011-02-01 /pmc/articles/PMC3049577/ /pubmed/21285973 http://dx.doi.org/10.1038/sj.bjc.6606090 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Madsen, M
Andersen, P K
Gerster, M
Nybo Andersen, A-M
Christensen, K
Osler, M
Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
title Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
title_full Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
title_fullStr Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
title_full_unstemmed Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
title_short Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
title_sort does the association of education with breast cancer replicate within twin pairs? a register-based study on danish female twins
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049577/
https://www.ncbi.nlm.nih.gov/pubmed/21285973
http://dx.doi.org/10.1038/sj.bjc.6606090
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