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Expression of BMP-7 in human gastric cancer and its clinical significance

BACKGROUND: Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer...

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Autores principales: Aoki, M, Ishigami, S, Uenosono, Y, Arigami, T, Uchikado, Y, Kita, Y, Kurahara, H, Matsumoto, M, Ueno, S, Natsugoe, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049585/
https://www.ncbi.nlm.nih.gov/pubmed/21224856
http://dx.doi.org/10.1038/sj.bjc.6606075
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author Aoki, M
Ishigami, S
Uenosono, Y
Arigami, T
Uchikado, Y
Kita, Y
Kurahara, H
Matsumoto, M
Ueno, S
Natsugoe, S
author_facet Aoki, M
Ishigami, S
Uenosono, Y
Arigami, T
Uchikado, Y
Kita, Y
Kurahara, H
Matsumoto, M
Ueno, S
Natsugoe, S
author_sort Aoki, M
collection PubMed
description BACKGROUND: Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer. METHODS: We immunohistochemically investigated the expression of BMP-7 in 233 gastric cancer patients to disclose the clinicopathological features of BMP-7-positive gastric cancer. RESULTS: Immunohistochemically, in human gastric cancer, BMP-7 expression was identified in cellular membranes but also in the cytoplasm of cancer cells. Bone morphogenetic protein-7-positive expression was found in 129 of 233 patients (55%). Bone morphogenetic protein-7 expression was correlated with tumour size, nodal involvement, lymphatic invasion, venous invasion and histology (P<0.05). Bone morphogenetic protein-7 expression was significantly correlated with patient postoperative outcome, especially in the undifferentiated group. Multivariate analysis revealed BMP-7 expression as one of the independent prognostic factors next to the depth of invasion and nodal involvement (P<0.01). CONCLUSIONS: From the data collected, it would be appropriate to conclude on the possible regulation of gastric cancer progression by autocrine or paracrine BMP-7 loops. We can use BMP-7 expression as one of the strong predictors of risk of tumour recurrence in gastric cancer.
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spelling pubmed-30495852012-02-15 Expression of BMP-7 in human gastric cancer and its clinical significance Aoki, M Ishigami, S Uenosono, Y Arigami, T Uchikado, Y Kita, Y Kurahara, H Matsumoto, M Ueno, S Natsugoe, S Br J Cancer Molecular Diagnostics BACKGROUND: Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer. METHODS: We immunohistochemically investigated the expression of BMP-7 in 233 gastric cancer patients to disclose the clinicopathological features of BMP-7-positive gastric cancer. RESULTS: Immunohistochemically, in human gastric cancer, BMP-7 expression was identified in cellular membranes but also in the cytoplasm of cancer cells. Bone morphogenetic protein-7-positive expression was found in 129 of 233 patients (55%). Bone morphogenetic protein-7 expression was correlated with tumour size, nodal involvement, lymphatic invasion, venous invasion and histology (P<0.05). Bone morphogenetic protein-7 expression was significantly correlated with patient postoperative outcome, especially in the undifferentiated group. Multivariate analysis revealed BMP-7 expression as one of the independent prognostic factors next to the depth of invasion and nodal involvement (P<0.01). CONCLUSIONS: From the data collected, it would be appropriate to conclude on the possible regulation of gastric cancer progression by autocrine or paracrine BMP-7 loops. We can use BMP-7 expression as one of the strong predictors of risk of tumour recurrence in gastric cancer. Nature Publishing Group 2011-02-15 2011-01-11 /pmc/articles/PMC3049585/ /pubmed/21224856 http://dx.doi.org/10.1038/sj.bjc.6606075 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Aoki, M
Ishigami, S
Uenosono, Y
Arigami, T
Uchikado, Y
Kita, Y
Kurahara, H
Matsumoto, M
Ueno, S
Natsugoe, S
Expression of BMP-7 in human gastric cancer and its clinical significance
title Expression of BMP-7 in human gastric cancer and its clinical significance
title_full Expression of BMP-7 in human gastric cancer and its clinical significance
title_fullStr Expression of BMP-7 in human gastric cancer and its clinical significance
title_full_unstemmed Expression of BMP-7 in human gastric cancer and its clinical significance
title_short Expression of BMP-7 in human gastric cancer and its clinical significance
title_sort expression of bmp-7 in human gastric cancer and its clinical significance
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049585/
https://www.ncbi.nlm.nih.gov/pubmed/21224856
http://dx.doi.org/10.1038/sj.bjc.6606075
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