Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

PML—RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecu...

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Autores principales: Saeed, S, Logie, C, Stunnenberg, H G, Martens, J H A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049592/
https://www.ncbi.nlm.nih.gov/pubmed/21245861
http://dx.doi.org/10.1038/sj.bjc.6606095
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author Saeed, S
Logie, C
Stunnenberg, H G
Martens, J H A
author_facet Saeed, S
Logie, C
Stunnenberg, H G
Martens, J H A
author_sort Saeed, S
collection PubMed
description PML—RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML–RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.
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spelling pubmed-30495922012-02-15 Genome-wide functions of PML–RARα in acute promyelocytic leukaemia Saeed, S Logie, C Stunnenberg, H G Martens, J H A Br J Cancer Minireview PML—RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML–RARα target genes, its interplay with RXR and deregulation of epigenetic modifications. Nature Publishing Group 2011-02-15 2011-01-18 /pmc/articles/PMC3049592/ /pubmed/21245861 http://dx.doi.org/10.1038/sj.bjc.6606095 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Saeed, S
Logie, C
Stunnenberg, H G
Martens, J H A
Genome-wide functions of PML–RARα in acute promyelocytic leukaemia
title Genome-wide functions of PML–RARα in acute promyelocytic leukaemia
title_full Genome-wide functions of PML–RARα in acute promyelocytic leukaemia
title_fullStr Genome-wide functions of PML–RARα in acute promyelocytic leukaemia
title_full_unstemmed Genome-wide functions of PML–RARα in acute promyelocytic leukaemia
title_short Genome-wide functions of PML–RARα in acute promyelocytic leukaemia
title_sort genome-wide functions of pml–rarα in acute promyelocytic leukaemia
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049592/
https://www.ncbi.nlm.nih.gov/pubmed/21245861
http://dx.doi.org/10.1038/sj.bjc.6606095
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