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Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease

BACKGROUND: The molecular chaperone heat shock protein-90 (Hsp90) is a promising cancer drug target, but current Hsp90-based therapy has so far shown limited activity in the clinic. METHODS: We tested the efficacy of a novel mitochondrial-targeted, small-molecule Hsp90 inhibitor, Gamitrinib (GA mito...

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Detalles Bibliográficos
Autores principales:	Kang, B H, Tavecchio, M, Goel, H L, Hsieh, C-C, Garlick, D S, Raskett, C M, Lian, J B, Stein, G S, Languino, L R, Altieri, D C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049604/ https://www.ncbi.nlm.nih.gov/pubmed/21285984 http://dx.doi.org/10.1038/bjc.2011.9

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