Cargando…

Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.

The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip, single dose at commencement), N-methylnitrosourea (MNU) (20 mg/kg, ip, 4 doses at days 2, 5,...

Descripción completa

Detalles Bibliográficos
Autores principales: Jang, J. J., Cho, K. J., Lee, Y. S., Bae, J. H.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049677/
https://www.ncbi.nlm.nih.gov/pubmed/1888447
_version_ 1782199251810385920
author Jang, J. J.
Cho, K. J.
Lee, Y. S.
Bae, J. H.
author_facet Jang, J. J.
Cho, K. J.
Lee, Y. S.
Bae, J. H.
author_sort Jang, J. J.
collection PubMed
description The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip, single dose at commencement), N-methylnitrosourea (MNU) (20 mg/kg, ip, 4 doses at days 2, 5, 8, and 11), and N,N-dibutylnitrosamine (DBN) (0.05% in drinking water during weeks 3 and 4). Group 3 received vehicles without carcinogens during the initiation period. Group 4 served as the untreated control. After this initiating procedure, Groups 2 and 3 were administered a diet containing 0.01% CAP. All surviving animals were killed 20 weeks after the beginning of the experiment and the target organs examined histopathologically. The induction of GST-P+ hepatic foci in rats treated with carcinogens was significantly inhibited by treatment with CAP. CAP treatment significantly decreased the incidence of adenoma of the lung but increased the incidence of papillary or nodular (PN) hyperplasia of the urinary bladder. The tumor incidence of other organs, such as the kidney and thyroid, was not significantly different from the corresponding controls. These results demonstrated that concurrent treatment with CAP not only can inhibit carcinogenesis but can also enhance it depending on the organ. Thus, this wide-spectrum initiation model could be used to confirm organ-specific modification potential and, in addition, demonstrate different modifying effects of CAP on liver, lung, and bladder carcinogenesis.
format Text
id pubmed-3049677
institution National Center for Biotechnology Information
language English
publishDate 1991
publisher Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-30496772011-03-09 Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat. Jang, J. J. Cho, K. J. Lee, Y. S. Bae, J. H. J Korean Med Sci Research Article The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip, single dose at commencement), N-methylnitrosourea (MNU) (20 mg/kg, ip, 4 doses at days 2, 5, 8, and 11), and N,N-dibutylnitrosamine (DBN) (0.05% in drinking water during weeks 3 and 4). Group 3 received vehicles without carcinogens during the initiation period. Group 4 served as the untreated control. After this initiating procedure, Groups 2 and 3 were administered a diet containing 0.01% CAP. All surviving animals were killed 20 weeks after the beginning of the experiment and the target organs examined histopathologically. The induction of GST-P+ hepatic foci in rats treated with carcinogens was significantly inhibited by treatment with CAP. CAP treatment significantly decreased the incidence of adenoma of the lung but increased the incidence of papillary or nodular (PN) hyperplasia of the urinary bladder. The tumor incidence of other organs, such as the kidney and thyroid, was not significantly different from the corresponding controls. These results demonstrated that concurrent treatment with CAP not only can inhibit carcinogenesis but can also enhance it depending on the organ. Thus, this wide-spectrum initiation model could be used to confirm organ-specific modification potential and, in addition, demonstrate different modifying effects of CAP on liver, lung, and bladder carcinogenesis. Korean Academy of Medical Sciences 1991-03 /pmc/articles/PMC3049677/ /pubmed/1888447 Text en
spellingShingle Research Article
Jang, J. J.
Cho, K. J.
Lee, Y. S.
Bae, J. H.
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
title Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
title_full Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
title_fullStr Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
title_full_unstemmed Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
title_short Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
title_sort different modifying responses of capsaicin in a wide-spectrum initiation model of f344 rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049677/
https://www.ncbi.nlm.nih.gov/pubmed/1888447
work_keys_str_mv AT jangjj differentmodifyingresponsesofcapsaicininawidespectruminitiationmodeloff344rat
AT chokj differentmodifyingresponsesofcapsaicininawidespectruminitiationmodeloff344rat
AT leeys differentmodifyingresponsesofcapsaicininawidespectruminitiationmodeloff344rat
AT baejh differentmodifyingresponsesofcapsaicininawidespectruminitiationmodeloff344rat