High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor XL888

BACKGROUND: Many proteins that are dysregulated or mutated in cancer cells rely on the molecular chaperone HSP90 for their proper folding and activity, which has led to considerable interest in HSP90 as a cancer drug target. The diverse array of HSP90 client proteins encompasses oncogenic drivers, c...

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Detalles Bibliográficos
Autores principales: Lyman, Susan K., Crawley, Suzanne C., Gong, Ruoyu, Adamkewicz, Joanne I., McGrath, Garth, Chew, Jason Y., Choi, Jennifer, Holst, Charles R., Goon, Leanne H., Detmer, Scott A., Vaclavikova, Jana, Gerritsen, Mary E., Blake, Robert A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049797/
https://www.ncbi.nlm.nih.gov/pubmed/21408192
http://dx.doi.org/10.1371/journal.pone.0017692

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