ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1

ABL gene translocations create constitutively active tyrosine kinases that are causative in chronic myeloid leukemia, acute lymphocytic leukemia and other hematopoietic malignancies. Consistent retention of ABL SH3/SH2 autoinhibitory domains, however, suggests that these leukemogenic tyrosine kinase...

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Detalles Bibliográficos
Autores principales: Thai, M, Ting, P Y, McLaughlin, J, Cheng, D, Müschen, M, Witte, O N, Colicelli, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049868/
https://www.ncbi.nlm.nih.gov/pubmed/21102429
http://dx.doi.org/10.1038/leu.2010.268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049868/
https://www.ncbi.nlm.nih.gov/pubmed/21102429
http://dx.doi.org/10.1038/leu.2010.268

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