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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
We conducted a multi-stage, genome-wide association study (GWAS) of bladder cancer with a primary scan of 589,299 single nucleotide polymorphisms (SNPs) in 3,532 cases and 5,120 controls of European descent (5 studies) followed by a replication strategy, which included 8,381 cases and 48,275 control...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049891/ https://www.ncbi.nlm.nih.gov/pubmed/20972438 http://dx.doi.org/10.1038/ng.687 |
| _version_ | 1782199283696533504 |
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| author | Rothman, Nathaniel Garcia-Closas, Montserrat Chatterjee, Nilanjan Malats, Nuria Wu, Xifeng Figueroa, Jonine Real, Francisco X Van Den Berg, David Matullo, Giuseppe Baris, Dalsu Thun, Michael Kiemeney, Lambertus A Vineis, Paolo De Vivo, Immaculata Albanes, Demetrius Purdue, Mark P Rafnar, Thorunn Hildebrandt, Michelle A T Kiltie, Anne E Cussenot, Olivier Golka, Klaus Kumar, Rajiv Taylor, Jack A Mayordomo, Jose I Jacobs, Kevin B Kogevinas, Manolis Hutchinson, Amy Wang, Zhaoming Fu, Yi-Ping Prokunina-Olsson, Ludmila Burdette, Laurie Yeager, Meredith Wheeler, William Tardón, Adonina Serra, Consol Carrato, Alfredo García-Closas, Reina Lloreta, Josep Johnson, Alison Schwenn, Molly Karagas, Margaret R Schned, Alan Andriole, Gerald Grubb, Robert Black, Amanda Jacobs, Eric J Diver, W Ryan Gapstur, Susan M Weinstein, Stephanie J Virtamo, Jarmo Cortessis, Victoria K Gago-Dominguez, Manuela Pike, Malcolm C Stern, Mariana C Yuan, Jian-Min Hunter, David McGrath, Monica Dinney, Colin P Czerniak, Bogdan Chen, Meng Yang, Hushan Vermeulen, Sita H Aben, Katja K Witjes, J Alfred Makkinje, Remco R Sulem, Patrick Besenbacher, Soren Stefansson, Kari Riboli, Elio Brennan, Paul Panico, Salvatore Navarro, Carmen Allen, Naomi E Bueno-de-Mesquita, H Bas Trichopoulos, Dimitrios Caporaso, Neil Landi, Maria Teresa Canzian, Federico Ljungberg, Borje Tjonneland, Anne Clavel-Chapelon, Francoise Bishop, David T Teo, Mark T W Knowles, Margaret A Guarrera, Simonetta Polidoro, Silvia Ricceri, Fulvio Sacerdote, Carlotta Allione, Alessandra Cancel-Tassin, Geraldine Selinski, Silvia Hengstler, Jan G Dietrich, Holger Fletcher, Tony Rudnai, Peter Gurzau, Eugen Koppova, Kvetoslava Bolick, Sophia C E Godfrey, Ashley Xu, Zongli Sanz-Velez, José I García-Prats, María D Sanchez, Manuel Valdivia, Gabriel Porru, Stefano Benhamou, Simone Hoover, Robert N Fraumeni, Joseph F Silverman, Debra T Chanock, Stephen J |
| author_facet | Rothman, Nathaniel Garcia-Closas, Montserrat Chatterjee, Nilanjan Malats, Nuria Wu, Xifeng Figueroa, Jonine Real, Francisco X Van Den Berg, David Matullo, Giuseppe Baris, Dalsu Thun, Michael Kiemeney, Lambertus A Vineis, Paolo De Vivo, Immaculata Albanes, Demetrius Purdue, Mark P Rafnar, Thorunn Hildebrandt, Michelle A T Kiltie, Anne E Cussenot, Olivier Golka, Klaus Kumar, Rajiv Taylor, Jack A Mayordomo, Jose I Jacobs, Kevin B Kogevinas, Manolis Hutchinson, Amy Wang, Zhaoming Fu, Yi-Ping Prokunina-Olsson, Ludmila Burdette, Laurie Yeager, Meredith Wheeler, William Tardón, Adonina Serra, Consol Carrato, Alfredo García-Closas, Reina Lloreta, Josep Johnson, Alison Schwenn, Molly Karagas, Margaret R Schned, Alan Andriole, Gerald Grubb, Robert Black, Amanda Jacobs, Eric J Diver, W Ryan Gapstur, Susan M Weinstein, Stephanie J Virtamo, Jarmo Cortessis, Victoria K Gago-Dominguez, Manuela Pike, Malcolm C Stern, Mariana C Yuan, Jian-Min Hunter, David McGrath, Monica Dinney, Colin P Czerniak, Bogdan Chen, Meng Yang, Hushan Vermeulen, Sita H Aben, Katja K Witjes, J Alfred Makkinje, Remco R Sulem, Patrick Besenbacher, Soren Stefansson, Kari Riboli, Elio Brennan, Paul Panico, Salvatore Navarro, Carmen Allen, Naomi E Bueno-de-Mesquita, H Bas Trichopoulos, Dimitrios Caporaso, Neil Landi, Maria Teresa Canzian, Federico Ljungberg, Borje Tjonneland, Anne Clavel-Chapelon, Francoise Bishop, David T Teo, Mark T W Knowles, Margaret A Guarrera, Simonetta Polidoro, Silvia Ricceri, Fulvio Sacerdote, Carlotta Allione, Alessandra Cancel-Tassin, Geraldine Selinski, Silvia Hengstler, Jan G Dietrich, Holger Fletcher, Tony Rudnai, Peter Gurzau, Eugen Koppova, Kvetoslava Bolick, Sophia C E Godfrey, Ashley Xu, Zongli Sanz-Velez, José I García-Prats, María D Sanchez, Manuel Valdivia, Gabriel Porru, Stefano Benhamou, Simone Hoover, Robert N Fraumeni, Joseph F Silverman, Debra T Chanock, Stephen J |
| author_sort | Rothman, Nathaniel |
| collection | PubMed |
| description | We conducted a multi-stage, genome-wide association study (GWAS) of bladder cancer with a primary scan of 589,299 single nucleotide polymorphisms (SNPs) in 3,532 cases and 5,120 controls of European descent (5 studies) followed by a replication strategy, which included 8,381 cases and 48,275 controls (16 studies). In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1; rs1014971, (P=8×10(−12)) maps to a non-genic region of chromosome 22q13.1; rs8102137 (P=2×10(−11)) on 19q12 maps to CCNE1; and rs11892031 (P=1×10(−7)) maps to the UGT1A cluster on 2q37.1. We confirmed four previous GWAS associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P=4×10(−11)) and a tag SNP for NAT2 acetylation status (P=4×10(−11)), as well as demonstrated smoking interactions with both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into mechanisms of carcinogenesis. |
| format | Text |
| id | pubmed-3049891 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30498912011-05-01 A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci Rothman, Nathaniel Garcia-Closas, Montserrat Chatterjee, Nilanjan Malats, Nuria Wu, Xifeng Figueroa, Jonine Real, Francisco X Van Den Berg, David Matullo, Giuseppe Baris, Dalsu Thun, Michael Kiemeney, Lambertus A Vineis, Paolo De Vivo, Immaculata Albanes, Demetrius Purdue, Mark P Rafnar, Thorunn Hildebrandt, Michelle A T Kiltie, Anne E Cussenot, Olivier Golka, Klaus Kumar, Rajiv Taylor, Jack A Mayordomo, Jose I Jacobs, Kevin B Kogevinas, Manolis Hutchinson, Amy Wang, Zhaoming Fu, Yi-Ping Prokunina-Olsson, Ludmila Burdette, Laurie Yeager, Meredith Wheeler, William Tardón, Adonina Serra, Consol Carrato, Alfredo García-Closas, Reina Lloreta, Josep Johnson, Alison Schwenn, Molly Karagas, Margaret R Schned, Alan Andriole, Gerald Grubb, Robert Black, Amanda Jacobs, Eric J Diver, W Ryan Gapstur, Susan M Weinstein, Stephanie J Virtamo, Jarmo Cortessis, Victoria K Gago-Dominguez, Manuela Pike, Malcolm C Stern, Mariana C Yuan, Jian-Min Hunter, David McGrath, Monica Dinney, Colin P Czerniak, Bogdan Chen, Meng Yang, Hushan Vermeulen, Sita H Aben, Katja K Witjes, J Alfred Makkinje, Remco R Sulem, Patrick Besenbacher, Soren Stefansson, Kari Riboli, Elio Brennan, Paul Panico, Salvatore Navarro, Carmen Allen, Naomi E Bueno-de-Mesquita, H Bas Trichopoulos, Dimitrios Caporaso, Neil Landi, Maria Teresa Canzian, Federico Ljungberg, Borje Tjonneland, Anne Clavel-Chapelon, Francoise Bishop, David T Teo, Mark T W Knowles, Margaret A Guarrera, Simonetta Polidoro, Silvia Ricceri, Fulvio Sacerdote, Carlotta Allione, Alessandra Cancel-Tassin, Geraldine Selinski, Silvia Hengstler, Jan G Dietrich, Holger Fletcher, Tony Rudnai, Peter Gurzau, Eugen Koppova, Kvetoslava Bolick, Sophia C E Godfrey, Ashley Xu, Zongli Sanz-Velez, José I García-Prats, María D Sanchez, Manuel Valdivia, Gabriel Porru, Stefano Benhamou, Simone Hoover, Robert N Fraumeni, Joseph F Silverman, Debra T Chanock, Stephen J Nat Genet Article We conducted a multi-stage, genome-wide association study (GWAS) of bladder cancer with a primary scan of 589,299 single nucleotide polymorphisms (SNPs) in 3,532 cases and 5,120 controls of European descent (5 studies) followed by a replication strategy, which included 8,381 cases and 48,275 controls (16 studies). In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1; rs1014971, (P=8×10(−12)) maps to a non-genic region of chromosome 22q13.1; rs8102137 (P=2×10(−11)) on 19q12 maps to CCNE1; and rs11892031 (P=1×10(−7)) maps to the UGT1A cluster on 2q37.1. We confirmed four previous GWAS associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P=4×10(−11)) and a tag SNP for NAT2 acetylation status (P=4×10(−11)), as well as demonstrated smoking interactions with both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into mechanisms of carcinogenesis. 2010-10-24 2010-11 /pmc/articles/PMC3049891/ /pubmed/20972438 http://dx.doi.org/10.1038/ng.687 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Rothman, Nathaniel Garcia-Closas, Montserrat Chatterjee, Nilanjan Malats, Nuria Wu, Xifeng Figueroa, Jonine Real, Francisco X Van Den Berg, David Matullo, Giuseppe Baris, Dalsu Thun, Michael Kiemeney, Lambertus A Vineis, Paolo De Vivo, Immaculata Albanes, Demetrius Purdue, Mark P Rafnar, Thorunn Hildebrandt, Michelle A T Kiltie, Anne E Cussenot, Olivier Golka, Klaus Kumar, Rajiv Taylor, Jack A Mayordomo, Jose I Jacobs, Kevin B Kogevinas, Manolis Hutchinson, Amy Wang, Zhaoming Fu, Yi-Ping Prokunina-Olsson, Ludmila Burdette, Laurie Yeager, Meredith Wheeler, William Tardón, Adonina Serra, Consol Carrato, Alfredo García-Closas, Reina Lloreta, Josep Johnson, Alison Schwenn, Molly Karagas, Margaret R Schned, Alan Andriole, Gerald Grubb, Robert Black, Amanda Jacobs, Eric J Diver, W Ryan Gapstur, Susan M Weinstein, Stephanie J Virtamo, Jarmo Cortessis, Victoria K Gago-Dominguez, Manuela Pike, Malcolm C Stern, Mariana C Yuan, Jian-Min Hunter, David McGrath, Monica Dinney, Colin P Czerniak, Bogdan Chen, Meng Yang, Hushan Vermeulen, Sita H Aben, Katja K Witjes, J Alfred Makkinje, Remco R Sulem, Patrick Besenbacher, Soren Stefansson, Kari Riboli, Elio Brennan, Paul Panico, Salvatore Navarro, Carmen Allen, Naomi E Bueno-de-Mesquita, H Bas Trichopoulos, Dimitrios Caporaso, Neil Landi, Maria Teresa Canzian, Federico Ljungberg, Borje Tjonneland, Anne Clavel-Chapelon, Francoise Bishop, David T Teo, Mark T W Knowles, Margaret A Guarrera, Simonetta Polidoro, Silvia Ricceri, Fulvio Sacerdote, Carlotta Allione, Alessandra Cancel-Tassin, Geraldine Selinski, Silvia Hengstler, Jan G Dietrich, Holger Fletcher, Tony Rudnai, Peter Gurzau, Eugen Koppova, Kvetoslava Bolick, Sophia C E Godfrey, Ashley Xu, Zongli Sanz-Velez, José I García-Prats, María D Sanchez, Manuel Valdivia, Gabriel Porru, Stefano Benhamou, Simone Hoover, Robert N Fraumeni, Joseph F Silverman, Debra T Chanock, Stephen J A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_full | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_fullStr | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_full_unstemmed | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_short | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_sort | multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049891/ https://www.ncbi.nlm.nih.gov/pubmed/20972438 http://dx.doi.org/10.1038/ng.687 |
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