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AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

Two intermingled hypothalamic neuron populations, specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC), positively and negatively influence feeding behavior respectively, possibly by reciprocally regulating downstream melanocortin receptors. However, the sufficienc...

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Autores principales: Aponte, Yexica, Atasoy, Deniz, Sternson, Scott M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049940/
https://www.ncbi.nlm.nih.gov/pubmed/21209617
http://dx.doi.org/10.1038/nn.2739
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author Aponte, Yexica
Atasoy, Deniz
Sternson, Scott M.
author_facet Aponte, Yexica
Atasoy, Deniz
Sternson, Scott M.
author_sort Aponte, Yexica
collection PubMed
description Two intermingled hypothalamic neuron populations, specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC), positively and negatively influence feeding behavior respectively, possibly by reciprocally regulating downstream melanocortin receptors. However, the sufficiency of these neurons to control behavior, and the relationship of their activity to the magnitude and dynamics of feeding are unknown. To measure this, we used channelrhodopsin-2 for cell type-specific photostimulation. Activation of only 800 AGRP neurons in mice evoked voracious feeding within minutes. The behavioral response increased with photoexcitable neuron number, photostimulation frequency, and stimulus duration. Conversely, POMC neuron stimulation reduced food intake and body weight, which required melanocortin receptor signaling. However, AGRP neuron-mediated feeding was not dependent on suppressing this melanocortin pathway, indicating that AGRP neurons directly engage feeding circuits. Furthermore, feeding was evoked selectively over drinking without training or prior photostimulus exposure, which suggests that AGRP neurons serve a dedicated role coordinating this complex behavior.
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spelling pubmed-30499402011-09-01 AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training Aponte, Yexica Atasoy, Deniz Sternson, Scott M. Nat Neurosci Article Two intermingled hypothalamic neuron populations, specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC), positively and negatively influence feeding behavior respectively, possibly by reciprocally regulating downstream melanocortin receptors. However, the sufficiency of these neurons to control behavior, and the relationship of their activity to the magnitude and dynamics of feeding are unknown. To measure this, we used channelrhodopsin-2 for cell type-specific photostimulation. Activation of only 800 AGRP neurons in mice evoked voracious feeding within minutes. The behavioral response increased with photoexcitable neuron number, photostimulation frequency, and stimulus duration. Conversely, POMC neuron stimulation reduced food intake and body weight, which required melanocortin receptor signaling. However, AGRP neuron-mediated feeding was not dependent on suppressing this melanocortin pathway, indicating that AGRP neurons directly engage feeding circuits. Furthermore, feeding was evoked selectively over drinking without training or prior photostimulus exposure, which suggests that AGRP neurons serve a dedicated role coordinating this complex behavior. 2010-01-05 2011-03 /pmc/articles/PMC3049940/ /pubmed/21209617 http://dx.doi.org/10.1038/nn.2739 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Aponte, Yexica
Atasoy, Deniz
Sternson, Scott M.
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
title AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
title_full AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
title_fullStr AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
title_full_unstemmed AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
title_short AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
title_sort agrp neurons are sufficient to orchestrate feeding behavior rapidly and without training
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049940/
https://www.ncbi.nlm.nih.gov/pubmed/21209617
http://dx.doi.org/10.1038/nn.2739
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