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1-[2-(4-Nitro­phen­yl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetra­hydro­quinolin-4-yl]pyrrolidin-2-one monohydrate

The title compound, C(28)H(24)N(4)O(4)·H(2)O, crystallizes with two organic mol­ecules and two solvent water mol­ecules in the asymmetric unit. The most obvious difference between the mol­ecules is the torsion angles between the isoxazole ring and the benzene and phenyl rings [47.0 (2)/56.4 (2) and...

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Detalles Bibliográficos
Autores principales: Gutierrez, Margarita, Vallejos, Gabriel, Fernández, Carlos, Cárdenas, Alejandro, Brito, Iván
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050245/
https://www.ncbi.nlm.nih.gov/pubmed/21522681
http://dx.doi.org/10.1107/S1600536810052463
Descripción
Sumario:The title compound, C(28)H(24)N(4)O(4)·H(2)O, crystallizes with two organic mol­ecules and two solvent water mol­ecules in the asymmetric unit. The most obvious difference between the mol­ecules is the torsion angles between the isoxazole ring and the benzene and phenyl rings [47.0 (2)/56.4 (2) and 33.3 (2)/11.0 (2)°, respectively]. Another important difference is observed in the rotation of the nitro group with respect to the phenyl groups [3.5 (6) and 31.1 (6)°]. The pyrrolidinone fragment is cis oriented with respect to the 4-nitro­phenyl fragment. In the crystal, mol­ecules are linked into centrosymmetric R (4) (2)(8) and R (4) (4)(20) motifs by O—H⋯O and N—H⋯O inter­actions.