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The transcription factor MAFB antagonizes anti-viral responses by blockade of coactivator recruitment to IRF3
Viral infections induce Type I interferons (IFN-α and -β) that recruit unexposed cells in a self-amplifying response. We report that the transcription factor MAFB thwarts auto-amplification by a metastable switch behavior. MAFB acts as a weak positive basal regulator of transcription at the IFN-β pr...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050627/ https://www.ncbi.nlm.nih.gov/pubmed/20581830 http://dx.doi.org/10.1038/ni.1897 |