Local Ca(2+) Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca(2+) Signals Required for Specific Cell Functions

Store-operated Ca(2+) entry (SOCE) has been associated with two types of channels: CRAC channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and STIM1. While TRPC1 significantly contributes to SOCE and SOC channel activity, abrogation of Orai1 function eliminates SOCE an...

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Detalles Bibliográficos
Autores principales: Cheng, Kwong Tai, Liu, Xibao, Ong, Hwei Ling, Swaim, William, Ambudkar, Indu S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050638/
https://www.ncbi.nlm.nih.gov/pubmed/21408196
http://dx.doi.org/10.1371/journal.pbio.1001025

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