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The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design

BACKGROUND: Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention w...

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Autores principales: López-Cancio, Elena, Dorado, Laura, Millán, Mónica, Reverté, Silvia, Suñol, Anna, Massuet, Anna, Mataró, María, Galán, Amparo, Alzamora, Maite, Pera, Guillem, Torán, Pere, Dávalos, Antoni, Arenillas, Juan F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050686/
https://www.ncbi.nlm.nih.gov/pubmed/21329527
http://dx.doi.org/10.1186/1471-2377-11-22
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author López-Cancio, Elena
Dorado, Laura
Millán, Mónica
Reverté, Silvia
Suñol, Anna
Massuet, Anna
Mataró, María
Galán, Amparo
Alzamora, Maite
Pera, Guillem
Torán, Pere
Dávalos, Antoni
Arenillas, Juan F
author_facet López-Cancio, Elena
Dorado, Laura
Millán, Mónica
Reverté, Silvia
Suñol, Anna
Massuet, Anna
Mataró, María
Galán, Amparo
Alzamora, Maite
Pera, Guillem
Torán, Pere
Dávalos, Antoni
Arenillas, Juan F
author_sort López-Cancio, Elena
collection PubMed
description BACKGROUND: Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. METHODS/DESIGN: Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. DISCUSSION: The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.
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spelling pubmed-30506862011-03-09 The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design López-Cancio, Elena Dorado, Laura Millán, Mónica Reverté, Silvia Suñol, Anna Massuet, Anna Mataró, María Galán, Amparo Alzamora, Maite Pera, Guillem Torán, Pere Dávalos, Antoni Arenillas, Juan F BMC Neurol Study Protocol BACKGROUND: Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. METHODS/DESIGN: Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. DISCUSSION: The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition. BioMed Central 2011-02-17 /pmc/articles/PMC3050686/ /pubmed/21329527 http://dx.doi.org/10.1186/1471-2377-11-22 Text en Copyright ©2011 López-Cancio et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
López-Cancio, Elena
Dorado, Laura
Millán, Mónica
Reverté, Silvia
Suñol, Anna
Massuet, Anna
Mataró, María
Galán, Amparo
Alzamora, Maite
Pera, Guillem
Torán, Pere
Dávalos, Antoni
Arenillas, Juan F
The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
title The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
title_full The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
title_fullStr The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
title_full_unstemmed The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
title_short The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
title_sort population-based barcelona-asymptomatic intracranial atherosclerosis study (asia): rationale and design
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050686/
https://www.ncbi.nlm.nih.gov/pubmed/21329527
http://dx.doi.org/10.1186/1471-2377-11-22
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