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Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009

BACKGROUND: Salmonellosis is one of the most important foodborne diseases and a major threat to public health. Salmonella serotype Virchow ranks among the top five serovars in Europe. METHOD: A total of 153 strains isolated from different patients from 2004 through 2009 in Switzerland were further c...

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Autores principales: Bonalli, Mario, Stephan, Roger, Käppeli, Ursula, Cernela, Nicole, Adank, Luzius, Hächler, Herbert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050727/
https://www.ncbi.nlm.nih.gov/pubmed/21345197
http://dx.doi.org/10.1186/1471-2334-11-49
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author Bonalli, Mario
Stephan, Roger
Käppeli, Ursula
Cernela, Nicole
Adank, Luzius
Hächler, Herbert
author_facet Bonalli, Mario
Stephan, Roger
Käppeli, Ursula
Cernela, Nicole
Adank, Luzius
Hächler, Herbert
author_sort Bonalli, Mario
collection PubMed
description BACKGROUND: Salmonellosis is one of the most important foodborne diseases and a major threat to public health. Salmonella serotype Virchow ranks among the top five serovars in Europe. METHOD: A total of 153 strains isolated from different patients from 2004 through 2009 in Switzerland were further characterized by (i) assessing phenotypic antibiotic resistance profiles using the disk diffusion method and (ii) by genotyping using pulsed-field gel electrophoresis (PFGE) after macrorestriction with XbaI in order to evaluate strain relationship. RESULTS: The relative frequency of S. Virchow among other Salmonella serovars varied between 4(th )to 8(th )rank. The annual incidence ranged from 0.45/100'000 in 2004 to 0.40/100'000 in 2009. A total of 48 strains (32%) were resistant to one to 3 antimicrobials, 54 strains (36%) displayed resistance patterns to more than three antibiotics. No trend was identifiable over the years 2004 to 2009. We found a high prevalence (62%) of nalidixic acid resistant strains, suggesting an equally high rate of decreased fluoroqionolone susceptibility, whereas intermediate resistance to ciprofloxacin was negligible. Two strains were extended spectrum β-lactamase (ESBL) producers. Analysis of PFGE patterns uncovered a predominant cluster (similarity coefficient above 80%) consisting of 104 of the 153 strains. CONCLUSION: The worldwide increase of antibiotic resistances in Salmonella is an emerging public health problem. For Switzerland, no clear trend is identifiable over the years 2004 to 2009 for S. Virchow. Antimicrobial susceptibility and resistance profiles varied considerably within this period. Nevertheless, the situation in Switzerland coincided with findings in other European countries. Genotyping results of this strain collection revealed no evidence for an undetected outbreak within this time period.
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spelling pubmed-30507272011-03-09 Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009 Bonalli, Mario Stephan, Roger Käppeli, Ursula Cernela, Nicole Adank, Luzius Hächler, Herbert BMC Infect Dis Research Article BACKGROUND: Salmonellosis is one of the most important foodborne diseases and a major threat to public health. Salmonella serotype Virchow ranks among the top five serovars in Europe. METHOD: A total of 153 strains isolated from different patients from 2004 through 2009 in Switzerland were further characterized by (i) assessing phenotypic antibiotic resistance profiles using the disk diffusion method and (ii) by genotyping using pulsed-field gel electrophoresis (PFGE) after macrorestriction with XbaI in order to evaluate strain relationship. RESULTS: The relative frequency of S. Virchow among other Salmonella serovars varied between 4(th )to 8(th )rank. The annual incidence ranged from 0.45/100'000 in 2004 to 0.40/100'000 in 2009. A total of 48 strains (32%) were resistant to one to 3 antimicrobials, 54 strains (36%) displayed resistance patterns to more than three antibiotics. No trend was identifiable over the years 2004 to 2009. We found a high prevalence (62%) of nalidixic acid resistant strains, suggesting an equally high rate of decreased fluoroqionolone susceptibility, whereas intermediate resistance to ciprofloxacin was negligible. Two strains were extended spectrum β-lactamase (ESBL) producers. Analysis of PFGE patterns uncovered a predominant cluster (similarity coefficient above 80%) consisting of 104 of the 153 strains. CONCLUSION: The worldwide increase of antibiotic resistances in Salmonella is an emerging public health problem. For Switzerland, no clear trend is identifiable over the years 2004 to 2009 for S. Virchow. Antimicrobial susceptibility and resistance profiles varied considerably within this period. Nevertheless, the situation in Switzerland coincided with findings in other European countries. Genotyping results of this strain collection revealed no evidence for an undetected outbreak within this time period. BioMed Central 2011-02-23 /pmc/articles/PMC3050727/ /pubmed/21345197 http://dx.doi.org/10.1186/1471-2334-11-49 Text en Copyright ©2011 Bonalli et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bonalli, Mario
Stephan, Roger
Käppeli, Ursula
Cernela, Nicole
Adank, Luzius
Hächler, Herbert
Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009
title Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009
title_full Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009
title_fullStr Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009
title_full_unstemmed Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009
title_short Salmonella enterica serotype Virchow associated with human infections in Switzerland: 2004-2009
title_sort salmonella enterica serotype virchow associated with human infections in switzerland: 2004-2009
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050727/
https://www.ncbi.nlm.nih.gov/pubmed/21345197
http://dx.doi.org/10.1186/1471-2334-11-49
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