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Co-Administration of a Plasmid DNA Encoding IL-15 Improves Long-Term Protection of a Genetic Vaccine against Trypanosoma cruzi

BACKGROUND: Immunization of mice with the Trypanosoma cruzi trans-sialidase (TS) gene using plasmid DNA, adenoviral vector, and CpG-adjuvanted protein delivery has proven highly immunogenic and provides protection against acute lethal challenge. However, long-term protection induced by TS DNA vaccin...

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Detalles Bibliográficos
Autores principales:	Eickhoff, Christopher S., Vasconcelos, Jose R., Sullivan, Nicole L., Blazevic, Azra, Bruna-Romero, Oscar, Rodrigues, Mauricio M., Hoft, Daniel F.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050911/ https://www.ncbi.nlm.nih.gov/pubmed/21408124 http://dx.doi.org/10.1371/journal.pntd.0000983

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