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Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies
BACKGROUND: A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. METHODS AND FINDING...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050917/ https://www.ncbi.nlm.nih.gov/pubmed/21408128 http://dx.doi.org/10.1371/journal.pone.0017608 |
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| author | Wang, Li Wu, Xiao-Pan Zhang, Wei Zhu, Da-Hai Wang, Ying Li, Yan-Ping Tian, Yao Li, Rong-Cheng Li, Zhuo Zhu, Xinlin Li, Jun-Hong Cai, Jun Liu, Li Miao, Xiao-Ping Liu, Ying Li, Hui |
| author_facet | Wang, Li Wu, Xiao-Pan Zhang, Wei Zhu, Da-Hai Wang, Ying Li, Yan-Ping Tian, Yao Li, Rong-Cheng Li, Zhuo Zhu, Xinlin Li, Jun-Hong Cai, Jun Liu, Li Miao, Xiao-Ping Liu, Ying Li, Hui |
| author_sort | Wang, Li |
| collection | PubMed |
| description | BACKGROUND: A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. METHODS AND FINDINGS: We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464–0.628, P = 4.068×10(−16) and OR = 0.696, 95%CI: 0.601–0.806, P = 1.062×10(−6), respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441–0.833, P = 0.002). CONCLUSION: Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies. |
| format | Text |
| id | pubmed-3050917 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30509172011-03-15 Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies Wang, Li Wu, Xiao-Pan Zhang, Wei Zhu, Da-Hai Wang, Ying Li, Yan-Ping Tian, Yao Li, Rong-Cheng Li, Zhuo Zhu, Xinlin Li, Jun-Hong Cai, Jun Liu, Li Miao, Xiao-Ping Liu, Ying Li, Hui PLoS One Research Article BACKGROUND: A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. METHODS AND FINDINGS: We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464–0.628, P = 4.068×10(−16) and OR = 0.696, 95%CI: 0.601–0.806, P = 1.062×10(−6), respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441–0.833, P = 0.002). CONCLUSION: Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies. Public Library of Science 2011-03-08 /pmc/articles/PMC3050917/ /pubmed/21408128 http://dx.doi.org/10.1371/journal.pone.0017608 Text en Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Wang, Li Wu, Xiao-Pan Zhang, Wei Zhu, Da-Hai Wang, Ying Li, Yan-Ping Tian, Yao Li, Rong-Cheng Li, Zhuo Zhu, Xinlin Li, Jun-Hong Cai, Jun Liu, Li Miao, Xiao-Ping Liu, Ying Li, Hui Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies |
| title | Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies |
| title_full | Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies |
| title_fullStr | Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies |
| title_full_unstemmed | Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies |
| title_short | Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies |
| title_sort | evaluation of genetic susceptibility loci for chronic hepatitis b in chinese: two independent case-control studies |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050917/ https://www.ncbi.nlm.nih.gov/pubmed/21408128 http://dx.doi.org/10.1371/journal.pone.0017608 |
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