MUTANT HUNTINGTIN BINDS THE MITOCHONDRIAL FISSION GTPASE DRP1 AND INCREASES ITS ENZYMATIC ACTIVTY

Huntington disease (HD) is an inherited and incurable neurodegenerative disorder caused by an abnormal polyglutamine (polyQ) expansion in huntingtin (HTT). PolyQ length determines disease onset and severity with a longer expansion causing earlier onset. The mechanisms of mutant HTT-mediated neurotox...

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Detalles Bibliográficos
Autores principales: Song, Wenjun, Chen, Jin, Petrilli, Alejandra, Liot, Geraldine, Klinglmayr, Eva, Zhou, Yue, Poquiz, Patrick, Tjong, Jonathan, Pouladi, Mahmoud A., Hayden, Michael R., Masliah, Eliezer, Ellisman, Mark, Rouiller, Isabelle, Schwarzenbacher, Robert, Bossy, Blaise, Perkins, Guy, Bossy-Wetzel, Ella
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051025/
https://www.ncbi.nlm.nih.gov/pubmed/21336284
http://dx.doi.org/10.1038/nm.2313

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