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Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium

The Bcl-2 adenovirus E1B 19 kDa-interacting protein 3 (Bnip3) is a pro-apoptotic BH3-only protein associated with the pathogenesis of many diseases, including cancer and cardiovascular disease. Studies over the past decade have provided insight into how Bnip3 induces mitochondrial dysfunction and su...

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Autor principal: Gustafsson, Åsa B.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051075/
https://www.ncbi.nlm.nih.gov/pubmed/21210091
http://dx.doi.org/10.1007/s00246-010-9876-5
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author Gustafsson, Åsa B.
author_facet Gustafsson, Åsa B.
author_sort Gustafsson, Åsa B.
collection PubMed
description The Bcl-2 adenovirus E1B 19 kDa-interacting protein 3 (Bnip3) is a pro-apoptotic BH3-only protein associated with the pathogenesis of many diseases, including cancer and cardiovascular disease. Studies over the past decade have provided insight into how Bnip3 induces mitochondrial dysfunction and subsequent cell death in cells. More recently, Bnip3 was identified as a potent inducer of autophagy in cells. However, the functional role of Bnip3-mediated autophagy has been difficult to define and remains controversial. New evidence has emerged suggesting that Bnip3 is an important regulator of mitochondrial turnover via autophagy in the myocardium. Also, studies suggest that the induction of Bnip3-dependent mitochondrial autophagy is a separately activated process independent of Bax/Bak and the mitochondrial permeability transition pore (mPTP). This review discusses the current understanding of the functional role that Bnip3 plays in the myocardium. Recent studies suggest that Bnip3 might have a dual function in the myocardium, where it regulates both mitochondrial turnover via autophagy and cell death and that these are two separate processes activated by Bnip3.
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spelling pubmed-30510752011-04-05 Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium Gustafsson, Åsa B. Pediatr Cardiol Riley Symposium The Bcl-2 adenovirus E1B 19 kDa-interacting protein 3 (Bnip3) is a pro-apoptotic BH3-only protein associated with the pathogenesis of many diseases, including cancer and cardiovascular disease. Studies over the past decade have provided insight into how Bnip3 induces mitochondrial dysfunction and subsequent cell death in cells. More recently, Bnip3 was identified as a potent inducer of autophagy in cells. However, the functional role of Bnip3-mediated autophagy has been difficult to define and remains controversial. New evidence has emerged suggesting that Bnip3 is an important regulator of mitochondrial turnover via autophagy in the myocardium. Also, studies suggest that the induction of Bnip3-dependent mitochondrial autophagy is a separately activated process independent of Bax/Bak and the mitochondrial permeability transition pore (mPTP). This review discusses the current understanding of the functional role that Bnip3 plays in the myocardium. Recent studies suggest that Bnip3 might have a dual function in the myocardium, where it regulates both mitochondrial turnover via autophagy and cell death and that these are two separate processes activated by Bnip3. Springer-Verlag 2011-01-06 2011 /pmc/articles/PMC3051075/ /pubmed/21210091 http://dx.doi.org/10.1007/s00246-010-9876-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Riley Symposium
Gustafsson, Åsa B.
Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
title Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
title_full Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
title_fullStr Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
title_full_unstemmed Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
title_short Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium
title_sort bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium
topic Riley Symposium
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051075/
https://www.ncbi.nlm.nih.gov/pubmed/21210091
http://dx.doi.org/10.1007/s00246-010-9876-5
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