Cargando…

Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study

To examine the relationship between birth characteristics and childhood cancer mortality, a retrospective cohort study of Korean children was conducted using data collected by the national birth register between 1995 and 2006, which were then individually linked to death data. A cohort of 6,479,406...

Descripción completa

Detalles Bibliográficos
Autores principales: Cha, Eun Shil, Kong, Kyoung Ae, Moon, Eun Kyeong, Khang, Young-Ho, Lee, Won Jin
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051079/
https://www.ncbi.nlm.nih.gov/pubmed/21394300
http://dx.doi.org/10.3346/jkms.2011.26.3.339
_version_ 1782199435964448768
author Cha, Eun Shil
Kong, Kyoung Ae
Moon, Eun Kyeong
Khang, Young-Ho
Lee, Won Jin
author_facet Cha, Eun Shil
Kong, Kyoung Ae
Moon, Eun Kyeong
Khang, Young-Ho
Lee, Won Jin
author_sort Cha, Eun Shil
collection PubMed
description To examine the relationship between birth characteristics and childhood cancer mortality, a retrospective cohort study of Korean children was conducted using data collected by the national birth register between 1995 and 2006, which were then individually linked to death data. A cohort of 6,479,406 children was followed from birth until their death or until December 31, 2006. Poisson regression analyses were used to calculate rate ratios of childhood cancer deaths according to birth characteristics. A total of 1,469 cancer deaths were noted and the childhood cancer mortality rate was found to be 3.43 per 100,000 person-years in Korea during the period of 1995-2006. The birth characteristics examined in this study (i.e. , birth weight, gestational age, multiple births, parental ages, and number of siblings) were generally found to be not significantly associated with childhood cancer mortality, and the associations did not vary meaningfully with gender nor with cancer sites. However, among children aged 5-11 yr, higher birth weight was associated with elevated childhood cancer mortality (rate ratio = 1.28, 95% confidence interval 1.04-1.58). Our results offer no overall associations between childhood cancer mortality and birth characteristics, but suggest that the association may be specific to age group.
format Text
id pubmed-3051079
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-30510792011-03-10 Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study Cha, Eun Shil Kong, Kyoung Ae Moon, Eun Kyeong Khang, Young-Ho Lee, Won Jin J Korean Med Sci Original Article To examine the relationship between birth characteristics and childhood cancer mortality, a retrospective cohort study of Korean children was conducted using data collected by the national birth register between 1995 and 2006, which were then individually linked to death data. A cohort of 6,479,406 children was followed from birth until their death or until December 31, 2006. Poisson regression analyses were used to calculate rate ratios of childhood cancer deaths according to birth characteristics. A total of 1,469 cancer deaths were noted and the childhood cancer mortality rate was found to be 3.43 per 100,000 person-years in Korea during the period of 1995-2006. The birth characteristics examined in this study (i.e. , birth weight, gestational age, multiple births, parental ages, and number of siblings) were generally found to be not significantly associated with childhood cancer mortality, and the associations did not vary meaningfully with gender nor with cancer sites. However, among children aged 5-11 yr, higher birth weight was associated with elevated childhood cancer mortality (rate ratio = 1.28, 95% confidence interval 1.04-1.58). Our results offer no overall associations between childhood cancer mortality and birth characteristics, but suggest that the association may be specific to age group. The Korean Academy of Medical Sciences 2011-03 2011-02-25 /pmc/articles/PMC3051079/ /pubmed/21394300 http://dx.doi.org/10.3346/jkms.2011.26.3.339 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cha, Eun Shil
Kong, Kyoung Ae
Moon, Eun Kyeong
Khang, Young-Ho
Lee, Won Jin
Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study
title Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study
title_full Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study
title_fullStr Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study
title_full_unstemmed Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study
title_short Childhood Cancer Mortality and Birth Characteristics in Korea: A National Population-based Birth Cohort Study
title_sort childhood cancer mortality and birth characteristics in korea: a national population-based birth cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051079/
https://www.ncbi.nlm.nih.gov/pubmed/21394300
http://dx.doi.org/10.3346/jkms.2011.26.3.339
work_keys_str_mv AT chaeunshil childhoodcancermortalityandbirthcharacteristicsinkoreaanationalpopulationbasedbirthcohortstudy
AT kongkyoungae childhoodcancermortalityandbirthcharacteristicsinkoreaanationalpopulationbasedbirthcohortstudy
AT mooneunkyeong childhoodcancermortalityandbirthcharacteristicsinkoreaanationalpopulationbasedbirthcohortstudy
AT khangyoungho childhoodcancermortalityandbirthcharacteristicsinkoreaanationalpopulationbasedbirthcohortstudy
AT leewonjin childhoodcancermortalityandbirthcharacteristicsinkoreaanationalpopulationbasedbirthcohortstudy