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Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study

Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonogra...

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Autores principales: Youn, Young Jin, Lee, Nam Seok, Kim, Jang-Young, Lee, Jun-Won, Sung, Joong-Kyung, Ahn, Sung-Gyun, You, Byung-Su, Lee, Seung-Hwan, Yoon, Junghan, Choe, Kyung-Hoon, Koh, Sang Baek, Park, Jong Ku
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051083/
https://www.ncbi.nlm.nih.gov/pubmed/21394304
http://dx.doi.org/10.3346/jkms.2011.26.3.365
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author Youn, Young Jin
Lee, Nam Seok
Kim, Jang-Young
Lee, Jun-Won
Sung, Joong-Kyung
Ahn, Sung-Gyun
You, Byung-Su
Lee, Seung-Hwan
Yoon, Junghan
Choe, Kyung-Hoon
Koh, Sang Baek
Park, Jong Ku
author_facet Youn, Young Jin
Lee, Nam Seok
Kim, Jang-Young
Lee, Jun-Won
Sung, Joong-Kyung
Ahn, Sung-Gyun
You, Byung-Su
Lee, Seung-Hwan
Yoon, Junghan
Choe, Kyung-Hoon
Koh, Sang Baek
Park, Jong Ku
author_sort Youn, Young Jin
collection PubMed
description Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r(2) = 0.043, P < 0.01 for men; r(2) = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS.
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spelling pubmed-30510832011-03-10 Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study Youn, Young Jin Lee, Nam Seok Kim, Jang-Young Lee, Jun-Won Sung, Joong-Kyung Ahn, Sung-Gyun You, Byung-Su Lee, Seung-Hwan Yoon, Junghan Choe, Kyung-Hoon Koh, Sang Baek Park, Jong Ku J Korean Med Sci Original Article Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r(2) = 0.043, P < 0.01 for men; r(2) = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS. The Korean Academy of Medical Sciences 2011-03 2011-02-25 /pmc/articles/PMC3051083/ /pubmed/21394304 http://dx.doi.org/10.3346/jkms.2011.26.3.365 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Youn, Young Jin
Lee, Nam Seok
Kim, Jang-Young
Lee, Jun-Won
Sung, Joong-Kyung
Ahn, Sung-Gyun
You, Byung-Su
Lee, Seung-Hwan
Yoon, Junghan
Choe, Kyung-Hoon
Koh, Sang Baek
Park, Jong Ku
Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study
title Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study
title_full Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study
title_fullStr Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study
title_full_unstemmed Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study
title_short Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study
title_sort normative values and correlates of mean common carotid intima-media thickness in the korean rural middle-aged population: the atherosclerosis risk of rural areas in korea general population (arirang) study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051083/
https://www.ncbi.nlm.nih.gov/pubmed/21394304
http://dx.doi.org/10.3346/jkms.2011.26.3.365
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