Cargando…
DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities
The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051164/ https://www.ncbi.nlm.nih.gov/pubmed/21403877 http://dx.doi.org/10.1155/2011/519652 |
_version_ | 1782199450444234752 |
---|---|
author | Trisina, Jessica Sunardi, Febrina Suhartono, Maggy T. Tjandrawinata, Raymond R. |
author_facet | Trisina, Jessica Sunardi, Febrina Suhartono, Maggy T. Tjandrawinata, Raymond R. |
author_sort | Trisina, Jessica |
collection | PubMed |
description | The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity. Fibrin plate and clot lysis assay were also done to examine thrombolytic properties. DLBS1033 was found to possess fibrinogenolytic activity on α-, β-, and γ-chain of fibrinogen. It also induced antiplatelet aggregation and prolonged blood clotting time, which further confirmed its antithrombotic properties. In addition, thrombolytic properties of DLBS1033 were shown with its fast and long-acting fibrinolytic activity, as well as its effective blood clot lysis activities. In conclusion, DLBS1033 conferred antithrombotic and thrombolytic action which could be used as a safe and promising oral thrombolytic drug. |
format | Text |
id | pubmed-3051164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30511642011-03-14 DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities Trisina, Jessica Sunardi, Febrina Suhartono, Maggy T. Tjandrawinata, Raymond R. J Biomed Biotechnol Research Article The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity. Fibrin plate and clot lysis assay were also done to examine thrombolytic properties. DLBS1033 was found to possess fibrinogenolytic activity on α-, β-, and γ-chain of fibrinogen. It also induced antiplatelet aggregation and prolonged blood clotting time, which further confirmed its antithrombotic properties. In addition, thrombolytic properties of DLBS1033 were shown with its fast and long-acting fibrinolytic activity, as well as its effective blood clot lysis activities. In conclusion, DLBS1033 conferred antithrombotic and thrombolytic action which could be used as a safe and promising oral thrombolytic drug. Hindawi Publishing Corporation 2011 2011-03-03 /pmc/articles/PMC3051164/ /pubmed/21403877 http://dx.doi.org/10.1155/2011/519652 Text en Copyright © 2011 Jessica Trisina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Trisina, Jessica Sunardi, Febrina Suhartono, Maggy T. Tjandrawinata, Raymond R. DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities |
title | DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities |
title_full | DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities |
title_fullStr | DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities |
title_full_unstemmed | DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities |
title_short | DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities |
title_sort | dlbs1033, a protein extract from lumbricus rubellus, possesses antithrombotic and thrombolytic activities |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051164/ https://www.ncbi.nlm.nih.gov/pubmed/21403877 http://dx.doi.org/10.1155/2011/519652 |
work_keys_str_mv | AT trisinajessica dlbs1033aproteinextractfromlumbricusrubelluspossessesantithromboticandthrombolyticactivities AT sunardifebrina dlbs1033aproteinextractfromlumbricusrubelluspossessesantithromboticandthrombolyticactivities AT suhartonomaggyt dlbs1033aproteinextractfromlumbricusrubelluspossessesantithromboticandthrombolyticactivities AT tjandrawinataraymondr dlbs1033aproteinextractfromlumbricusrubelluspossessesantithromboticandthrombolyticactivities |