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Molecular Mechanisms in Exercise-Induced Cardioprotection

Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic r...

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Detalles Bibliográficos
Autores principales: Golbidi, Saeid, Laher, Ismail
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051318/
https://www.ncbi.nlm.nih.gov/pubmed/21403846
http://dx.doi.org/10.4061/2011/972807
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author Golbidi, Saeid
Laher, Ismail
author_facet Golbidi, Saeid
Laher, Ismail
author_sort Golbidi, Saeid
collection PubMed
description Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic reticulum stress proteins, anatomical and physiological changes in the coronary arteries, changes in nitric oxide production, adaptational changes in cardiac mitochondria, increased autophagy, and improved function of sarcolemmal and/or mitochondrial ATP-sensitive potassium channels. It is currently unclear which of these protective mechanisms are essential for exercise-induced cardioprotection. However, most investigations focus on sarcolemmal KATP channels, NO production, and mitochondrial changes although it is very likely that other mechanisms may also exist. This paper discusses current information about these aforementioned topics and does not consider potentially important adaptations within blood or the autonomic nervous system. A better understanding of the molecular basis of exercise-induced cardioprotection will help to develop better therapeutic strategies.
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spelling pubmed-30513182011-03-14 Molecular Mechanisms in Exercise-Induced Cardioprotection Golbidi, Saeid Laher, Ismail Cardiol Res Pract Review Article Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic reticulum stress proteins, anatomical and physiological changes in the coronary arteries, changes in nitric oxide production, adaptational changes in cardiac mitochondria, increased autophagy, and improved function of sarcolemmal and/or mitochondrial ATP-sensitive potassium channels. It is currently unclear which of these protective mechanisms are essential for exercise-induced cardioprotection. However, most investigations focus on sarcolemmal KATP channels, NO production, and mitochondrial changes although it is very likely that other mechanisms may also exist. This paper discusses current information about these aforementioned topics and does not consider potentially important adaptations within blood or the autonomic nervous system. A better understanding of the molecular basis of exercise-induced cardioprotection will help to develop better therapeutic strategies. SAGE-Hindawi Access to Research 2011-03-06 /pmc/articles/PMC3051318/ /pubmed/21403846 http://dx.doi.org/10.4061/2011/972807 Text en Copyright © 2011 S. Golbidi and I. Laher. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Golbidi, Saeid
Laher, Ismail
Molecular Mechanisms in Exercise-Induced Cardioprotection
title Molecular Mechanisms in Exercise-Induced Cardioprotection
title_full Molecular Mechanisms in Exercise-Induced Cardioprotection
title_fullStr Molecular Mechanisms in Exercise-Induced Cardioprotection
title_full_unstemmed Molecular Mechanisms in Exercise-Induced Cardioprotection
title_short Molecular Mechanisms in Exercise-Induced Cardioprotection
title_sort molecular mechanisms in exercise-induced cardioprotection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051318/
https://www.ncbi.nlm.nih.gov/pubmed/21403846
http://dx.doi.org/10.4061/2011/972807
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