Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

The blood cell–specific kindlin-3 protein is required to activate leukocyte and platelet integrins. In line with this function, mutations in the KINDLIN-3 gene in man cause immunodeficiency and severe bleeding. Some patients also suffer from osteopetrosis, but the underlying mechanism leading to abn...

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Detalles Bibliográficos
Autores principales: Schmidt, Sarah, Nakchbandi, Inaam, Ruppert, Raphael, Kawelke, Nina, Hess, Michael W., Pfaller, Kristian, Jurdic, Pierre, Fässler, Reinhard, Moser, Markus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051823/
https://www.ncbi.nlm.nih.gov/pubmed/21357746
http://dx.doi.org/10.1083/jcb.201007141

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