(5S)-3-Chloro-5-[(1R,2S,5R)-2-isopropyl-5-methyl­cyclo­hex­yloxy]-4-(4-methyl­piperidin-1-yl)furan-2(5H)-one

The title compound, C(20)H(32)ClNO(3), was obtained via a tandem asymmetric Michael addition–elimination reaction of (5S)-3,4-dichloro-5-(l-menth­yloxy)furan-2(5H)-one and 4-methyl­piperidine in the presence of potassium fluoride. The furan­one ring is approximately planar [maximum atomic deviation...

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Detalles Bibliográficos
Autores principales: Wang, Xiao-Mei, Fu, Jian-Hua, Cai, Song-Liang, Wang, Zhao-Yang
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051989/
https://www.ncbi.nlm.nih.gov/pubmed/21522408
http://dx.doi.org/10.1107/S1600536811005216
Descripción
Sumario:The title compound, C(20)H(32)ClNO(3), was obtained via a tandem asymmetric Michael addition–elimination reaction of (5S)-3,4-dichloro-5-(l-menth­yloxy)furan-2(5H)-one and 4-methyl­piperidine in the presence of potassium fluoride. The furan­one ring is approximately planar [maximum atomic deviation = 0.022 (2) Å] while the cyclo­hexane ring adopts a chair conformation. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure.

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