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Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming
BACKGROUND: As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses. RESULTS: Here we characterise the effects of conditioned media from reovirus-infected, dying human melanoma cells (reoTCM), in the absen...
Autores principales: | Steele, Lynette, Errington, Fiona, Prestwich, Robin, Ilett, Elizabeth, Harrington, Kevin, Pandha, Hardev, Coffey, Matt, Selby, Peter, Vile, Richard, Melcher, Alan |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052210/ https://www.ncbi.nlm.nih.gov/pubmed/21338484 http://dx.doi.org/10.1186/1476-4598-10-20 |
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