Investigation into the Presence of and Serological Response to XMRV in CFS Patients

The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions de...

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Autores principales: Erlwein, Otto, Robinson, Mark J., Kaye, Steve, Wills, Gillian, Izui, Shozo, Wessely, Simon, Weber, Jonathan, Cleare, Anthony, Collier, David, McClure, Myra O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052320/
https://www.ncbi.nlm.nih.gov/pubmed/21408077
http://dx.doi.org/10.1371/journal.pone.0017592
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author Erlwein, Otto
Robinson, Mark J.
Kaye, Steve
Wills, Gillian
Izui, Shozo
Wessely, Simon
Weber, Jonathan
Cleare, Anthony
Collier, David
McClure, Myra O.
author_facet Erlwein, Otto
Robinson, Mark J.
Kaye, Steve
Wills, Gillian
Izui, Shozo
Wessely, Simon
Weber, Jonathan
Cleare, Anthony
Collier, David
McClure, Myra O.
author_sort Erlwein, Otto
collection PubMed
description The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.
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spelling pubmed-30523202011-03-15 Investigation into the Presence of and Serological Response to XMRV in CFS Patients Erlwein, Otto Robinson, Mark J. Kaye, Steve Wills, Gillian Izui, Shozo Wessely, Simon Weber, Jonathan Cleare, Anthony Collier, David McClure, Myra O. PLoS One Research Article The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK. Public Library of Science 2011-03-09 /pmc/articles/PMC3052320/ /pubmed/21408077 http://dx.doi.org/10.1371/journal.pone.0017592 Text en Erlwein et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Erlwein, Otto
Robinson, Mark J.
Kaye, Steve
Wills, Gillian
Izui, Shozo
Wessely, Simon
Weber, Jonathan
Cleare, Anthony
Collier, David
McClure, Myra O.
Investigation into the Presence of and Serological Response to XMRV in CFS Patients
title Investigation into the Presence of and Serological Response to XMRV in CFS Patients
title_full Investigation into the Presence of and Serological Response to XMRV in CFS Patients
title_fullStr Investigation into the Presence of and Serological Response to XMRV in CFS Patients
title_full_unstemmed Investigation into the Presence of and Serological Response to XMRV in CFS Patients
title_short Investigation into the Presence of and Serological Response to XMRV in CFS Patients
title_sort investigation into the presence of and serological response to xmrv in cfs patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052320/
https://www.ncbi.nlm.nih.gov/pubmed/21408077
http://dx.doi.org/10.1371/journal.pone.0017592
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