Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation

Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells’ response towards either a Th1- or Th2-cytokine profile offers potential therapeu...

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Detalles Bibliográficos
Autores principales: Veerapen, Natacha, Reddington, Faye, Salio, Mariolina, Cerundolo, Vincenzo, Besra, Gurdyal S.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052434/
https://www.ncbi.nlm.nih.gov/pubmed/21145749
http://dx.doi.org/10.1016/j.bmc.2010.11.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052434/
https://www.ncbi.nlm.nih.gov/pubmed/21145749
http://dx.doi.org/10.1016/j.bmc.2010.11.032

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