Cargando…

The natural history of non-human GB virus C in captive chimpanzees

GB virus C (GBV-C) is a common, non-pathogenic human virus that infects lymphocytes. Persistent GBV-C infection of humans with coexistent human immunodeficiency virus (HIV) infection is associated with prolonged survival, and GBV-C replication inhibits HIV replication in vitro. A GBV-C virus variant...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohr, Emma L., Murthy, Krishna K., McLinden, James H., Xiang, Jinhua, Stapleton, Jack T.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052534/
https://www.ncbi.nlm.nih.gov/pubmed/20861317
http://dx.doi.org/10.1099/vir.0.026088-0
_version_ 1782199686899171328
author Mohr, Emma L.
Murthy, Krishna K.
McLinden, James H.
Xiang, Jinhua
Stapleton, Jack T.
author_facet Mohr, Emma L.
Murthy, Krishna K.
McLinden, James H.
Xiang, Jinhua
Stapleton, Jack T.
author_sort Mohr, Emma L.
collection PubMed
description GB virus C (GBV-C) is a common, non-pathogenic human virus that infects lymphocytes. Persistent GBV-C infection of humans with coexistent human immunodeficiency virus (HIV) infection is associated with prolonged survival, and GBV-C replication inhibits HIV replication in vitro. A GBV-C virus variant was identified in chimpanzees in 1998 and was named GBV-C(trog) or GBV-C(cpz). The prevalence and natural history of GBV-C in chimpanzees remains uncharacterized. We examined the sera from 235 captive chimpanzees for the presence of GBV-C viraemia, viral persistence and clearance, E2 antibody kinetics and RNA sequence diversity. Sequences from six isolates shared more sequence identity with GBV-C(cpz) than with human GBV-C. The prevalence of GBV-C(cpz) viraemia and E2 antibody in chimpanzees (2.5 and 11 %, respectively) was similar to human GBV-C prevalence in healthy human blood donors (1.8 and 9 %, respectively). Persistent GBV-C(cpz) infection occurred in two of the six viraemic animals and was documented for 19 years in one animal. Host subspecies troglodyte GBV-C isolates and published verus GBV-C isolates shared a high degree of sequence identity, suggesting that GBV-C in chimpanzees should be identified with a chimpanzee designation (GBV-C(cpz)). The prevalence and natural history of chimpanzee GBV-C variant (GBV-C(cpz)) appears to be similar to human GBV-C infection. The chimpanzee could serve as an animal model to study HIV–GBV-C co-infection.
format Text
id pubmed-3052534
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Society for General Microbiology
record_format MEDLINE/PubMed
spelling pubmed-30525342012-01-01 The natural history of non-human GB virus C in captive chimpanzees Mohr, Emma L. Murthy, Krishna K. McLinden, James H. Xiang, Jinhua Stapleton, Jack T. J Gen Virol Animal GB virus C (GBV-C) is a common, non-pathogenic human virus that infects lymphocytes. Persistent GBV-C infection of humans with coexistent human immunodeficiency virus (HIV) infection is associated with prolonged survival, and GBV-C replication inhibits HIV replication in vitro. A GBV-C virus variant was identified in chimpanzees in 1998 and was named GBV-C(trog) or GBV-C(cpz). The prevalence and natural history of GBV-C in chimpanzees remains uncharacterized. We examined the sera from 235 captive chimpanzees for the presence of GBV-C viraemia, viral persistence and clearance, E2 antibody kinetics and RNA sequence diversity. Sequences from six isolates shared more sequence identity with GBV-C(cpz) than with human GBV-C. The prevalence of GBV-C(cpz) viraemia and E2 antibody in chimpanzees (2.5 and 11 %, respectively) was similar to human GBV-C prevalence in healthy human blood donors (1.8 and 9 %, respectively). Persistent GBV-C(cpz) infection occurred in two of the six viraemic animals and was documented for 19 years in one animal. Host subspecies troglodyte GBV-C isolates and published verus GBV-C isolates shared a high degree of sequence identity, suggesting that GBV-C in chimpanzees should be identified with a chimpanzee designation (GBV-C(cpz)). The prevalence and natural history of chimpanzee GBV-C variant (GBV-C(cpz)) appears to be similar to human GBV-C infection. The chimpanzee could serve as an animal model to study HIV–GBV-C co-infection. Society for General Microbiology 2011-01 /pmc/articles/PMC3052534/ /pubmed/20861317 http://dx.doi.org/10.1099/vir.0.026088-0 Text en Copyright © 2011, SGM
spellingShingle Animal
Mohr, Emma L.
Murthy, Krishna K.
McLinden, James H.
Xiang, Jinhua
Stapleton, Jack T.
The natural history of non-human GB virus C in captive chimpanzees
title The natural history of non-human GB virus C in captive chimpanzees
title_full The natural history of non-human GB virus C in captive chimpanzees
title_fullStr The natural history of non-human GB virus C in captive chimpanzees
title_full_unstemmed The natural history of non-human GB virus C in captive chimpanzees
title_short The natural history of non-human GB virus C in captive chimpanzees
title_sort natural history of non-human gb virus c in captive chimpanzees
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052534/
https://www.ncbi.nlm.nih.gov/pubmed/20861317
http://dx.doi.org/10.1099/vir.0.026088-0
work_keys_str_mv AT mohremmal thenaturalhistoryofnonhumangbviruscincaptivechimpanzees
AT murthykrishnak thenaturalhistoryofnonhumangbviruscincaptivechimpanzees
AT mclindenjamesh thenaturalhistoryofnonhumangbviruscincaptivechimpanzees
AT xiangjinhua thenaturalhistoryofnonhumangbviruscincaptivechimpanzees
AT stapletonjackt thenaturalhistoryofnonhumangbviruscincaptivechimpanzees
AT mohremmal naturalhistoryofnonhumangbviruscincaptivechimpanzees
AT murthykrishnak naturalhistoryofnonhumangbviruscincaptivechimpanzees
AT mclindenjamesh naturalhistoryofnonhumangbviruscincaptivechimpanzees
AT xiangjinhua naturalhistoryofnonhumangbviruscincaptivechimpanzees
AT stapletonjackt naturalhistoryofnonhumangbviruscincaptivechimpanzees