Cargando…

Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate

An experimental study was conducted to evaluate the hepatotoxic effects in the progeny of dams treated with methimazole, monocrotophos (MCP) and lead acetate. Female pregnant albino rats of Wistar kyoto strain were divided into five groups and treated as follows, from day 3 of pregnancy till weaning...

Descripción completa

Detalles Bibliográficos
Autores principales: Vanisthasree, K., Reddy, A. Gopala, Kalakumar, B., Haritha, C., Anilkumar, B.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052590/
https://www.ncbi.nlm.nih.gov/pubmed/21430926
http://dx.doi.org/10.4103/0971-6580.75868
_version_ 1782199695379005440
author Vanisthasree, K.
Reddy, A. Gopala
Kalakumar, B.
Haritha, C.
Anilkumar, B.
author_facet Vanisthasree, K.
Reddy, A. Gopala
Kalakumar, B.
Haritha, C.
Anilkumar, B.
author_sort Vanisthasree, K.
collection PubMed
description An experimental study was conducted to evaluate the hepatotoxic effects in the progeny of dams treated with methimazole, monocrotophos (MCP) and lead acetate. Female pregnant albino rats of Wistar kyoto strain were divided into five groups and treated as follows, from day 3 of pregnancy till weaning of pups on postnatal day (PND) 21. Group 1 served as sham control, group 2 received methimazole 0.02% in drinking water, group 3 received MCP (0.3 mg/kg orally), group 4 received lead acetate at 0.2% in drinking water and group 5 received MCP + lead acetate. Thyroid hormone profile was recorded on 14 (th)day of gestation in dams. Eight pups from each group were euthanized on PND 21 and 90, and liver tissues were collected for analysis. Thiobarbituric acid reactive substances (TBARS), protein carbonyls and reduced glutathione (GSH) of liver were studied on PND 21 and 90, while the activities of Na (+)/K(+)ATPase and Mg (2+)ATPase in the liver were studied on PND 90. T(3), T(4), GSH, Na(+)/K(+)ATPase and Mg(2+)ATPase were significantly (P<0.05) decreased, while TBARS and protein carbonyls were significantly (P < 0.05) increased in all the test groups as compared to group 1. From this study, it is concluded that both MCP and lead acetate have a possible influence on thyroid gland of dams as the thyroid profile was altered significantly and the hepatotoxic effects were comparable to those induced by methimazole.
format Text
id pubmed-3052590
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-30525902011-03-22 Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate Vanisthasree, K. Reddy, A. Gopala Kalakumar, B. Haritha, C. Anilkumar, B. Toxicol Int Original Article An experimental study was conducted to evaluate the hepatotoxic effects in the progeny of dams treated with methimazole, monocrotophos (MCP) and lead acetate. Female pregnant albino rats of Wistar kyoto strain were divided into five groups and treated as follows, from day 3 of pregnancy till weaning of pups on postnatal day (PND) 21. Group 1 served as sham control, group 2 received methimazole 0.02% in drinking water, group 3 received MCP (0.3 mg/kg orally), group 4 received lead acetate at 0.2% in drinking water and group 5 received MCP + lead acetate. Thyroid hormone profile was recorded on 14 (th)day of gestation in dams. Eight pups from each group were euthanized on PND 21 and 90, and liver tissues were collected for analysis. Thiobarbituric acid reactive substances (TBARS), protein carbonyls and reduced glutathione (GSH) of liver were studied on PND 21 and 90, while the activities of Na (+)/K(+)ATPase and Mg (2+)ATPase in the liver were studied on PND 90. T(3), T(4), GSH, Na(+)/K(+)ATPase and Mg(2+)ATPase were significantly (P<0.05) decreased, while TBARS and protein carbonyls were significantly (P < 0.05) increased in all the test groups as compared to group 1. From this study, it is concluded that both MCP and lead acetate have a possible influence on thyroid gland of dams as the thyroid profile was altered significantly and the hepatotoxic effects were comparable to those induced by methimazole. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3052590/ /pubmed/21430926 http://dx.doi.org/10.4103/0971-6580.75868 Text en © Toxicology International http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vanisthasree, K.
Reddy, A. Gopala
Kalakumar, B.
Haritha, C.
Anilkumar, B.
Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
title Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
title_full Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
title_fullStr Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
title_full_unstemmed Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
title_short Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
title_sort hepatotoxicity studies in the progeny of pregnant dams treated with methimazole, monocrotophos and lead acetate
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052590/
https://www.ncbi.nlm.nih.gov/pubmed/21430926
http://dx.doi.org/10.4103/0971-6580.75868
work_keys_str_mv AT vanisthasreek hepatotoxicitystudiesintheprogenyofpregnantdamstreatedwithmethimazolemonocrotophosandleadacetate
AT reddyagopala hepatotoxicitystudiesintheprogenyofpregnantdamstreatedwithmethimazolemonocrotophosandleadacetate
AT kalakumarb hepatotoxicitystudiesintheprogenyofpregnantdamstreatedwithmethimazolemonocrotophosandleadacetate
AT harithac hepatotoxicitystudiesintheprogenyofpregnantdamstreatedwithmethimazolemonocrotophosandleadacetate
AT anilkumarb hepatotoxicitystudiesintheprogenyofpregnantdamstreatedwithmethimazolemonocrotophosandleadacetate