Cargando…

Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain

BACKGROUND: The NIMA-related kinases (Neks) are widespread among eukaryotes. In mammalians they represent an evolutionarily conserved family of 11 serine/threonine kinases, with 40-45% amino acid sequence identity to the Aspergillus nidulans mitotic regulator NIMA within their catalytic domains. Nek...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meirelles, Gabriela V, Silva, Júlio C, Mendonça, Yuri de A, Ramos, Carlos HI, Torriani, Iris L, Kobarg, Jörg
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053220/ https://www.ncbi.nlm.nih.gov/pubmed/21320329 http://dx.doi.org/10.1186/1472-6807-11-12

Ejemplares similares

Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity
por: Moraes, Eduardo Cruz, et al.
Publicado: (2015)

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing
por: Basei, Fernanda Luisa, et al.
Publicado: (2015)

Characterization of the Human NEK7 Interactome Suggests Catalytic and Regulatory Properties Distinct from Those of NEK6
por: de Souza, Edmarcia Elisa, et al.
Publicado: (2014)

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin
por: Melo-Hanchuk, Talita D., et al.
Publicado: (2017)

Individual Globular Domains and Domain Unfolding Visualized in Overstretched Titin Molecules with Atomic Force Microscopy
por: Mártonfalvi, Zsolt, et al.
Publicado: (2014)

Sequential unfolding mechanisms of monomeric caspases
por: Joglekar, Isha, et al.
Publicado: (2023)

Sequential Unfolding Mechanisms of Monomeric Caspases
por: Joglekar, Isha, et al.
Publicado: (2023)

Slow Unfolding of Monomeric Proteins from Hyperthermophiles with Reversible Unfolding
por: Mukaiyama, Atsushi, et al.
Publicado: (2009)

Checking NEKs: Overcoming a Bottleneck in Human Diseases
por: Peres de Oliveira, Andressa, et al.
Publicado: (2020)

Expression of the NEK family in normal and cancer tissue: an immunohistochemical study
por: Melo-Hanchuk, Talita Diniz, et al.
Publicado: (2020)

Urea Unfolding Study of E. coli Alanyl-tRNA Synthetase and Its Monomeric Variants Proves the Role of C-Terminal Domain in Stability
por: Banerjee, Baisakhi, et al.
Publicado: (2015)

Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins
por: Okada, Jun, et al.
Publicado: (2010)

Low-resolution structural studies of human Stanniocalcin-1
por: Trindade, Daniel M, et al.
Publicado: (2009)

Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase
por: Marina Perez, Arina, et al.
Publicado: (2017)

Central domain deletions affect the SAXS solution structure and function of Yeast Hsp40 proteins Sis1 and Ydj1
por: Silva, Julio C, et al.
Publicado: (2011)

Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases
por: Matsumoto, Shunsuke, et al.
Publicado: (2013)

The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers
por: Finnigan, William, et al.
Publicado: (2020)

Insight into the Unfolding Properties of Chd64, a Small, Single Domain Protein with a Globular Core and Disordered Tails
por: Tarczewska, Aneta, et al.
Publicado: (2015)

Accelerated simulation of unfolding and refolding of a large single chain globular protein
por: Seddon, Gavin M., et al.
Publicado: (2012)

BtcA, A Class IA Type III Chaperone, Interacts with the BteA N-Terminal Domain through a Globular/Non-Globular Mechanism
por: Guttman, Chen, et al.
Publicado: (2013)

Scooby-domain: prediction of globular domains in protein sequence
por: George, Richard A., et al.
Publicado: (2005)

NEK10 interactome and depletion reveal new roles in mitochondria
por: Peres de Oliveira, Andressa, et al.
Publicado: (2020)

Computational Insights of Unfolding of N-Terminal Domain of TDP-43 Reveal the Conformational Heterogeneity in the Unfolding Pathway
por: Li, Ruiting, et al.
Publicado: (2022)

Solution structure of the human signaling protein RACK1
por: Gonçalves, Kaliandra A, et al.
Publicado: (2010)

Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
por: de Castro Ferezin, Camila, et al.
Publicado: (2022)

Dicarboxyl-terminated iron(ii) clathrochelates as ICD-reporters for globular proteins
por: Kovalska, Vladyslava, et al.
Publicado: (2019)

Novel missense ACAN gene variants linked to familial osteochondritis dissecans cluster in the C-terminal globular domain of aggrecan
por: Stattin, Eva-Lena, et al.
Publicado: (2022)

Structure and stability of recombinant bovine odorant-binding protein: II. Unfolding of the monomeric forms
por: Stepanenko, Olga V., et al.
Publicado: (2016)

Gene3D: Extensive prediction of globular domains in proteins
por: Lewis, Tony E, et al.
Publicado: (2018)

Gene3D: Extensive prediction of globular domains in proteins
por: Lewis, Tony E, et al.
Publicado: (2018)

Pipeline for transferring annotations between proteins beyond globular domains
por: Martínez‐Pérez, Elizabeth, et al.
Publicado: (2023)

Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity
por: Moretti, Matteo, et al.
Publicado: (2022)

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response
por: Pavan, Isadora Carolina Betim, et al.
Publicado: (2021)

NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells
por: Pavan, Isadora Carolina Betim, et al.
Publicado: (2023)

NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance
por: Ferezin, Camila de Castro, et al.
Publicado: (2021)

Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions
por: Almer, Gunter, et al.
Publicado: (2011)

Globular cluster systems
por: Ashman, Keith M, et al.
Publicado: (1998)

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
por: Haq, Tamanna, et al.
Publicado: (2015)

Sequence Evolution of the Intrinsically Disordered and Globular Domains of a Model Viral Oncoprotein
por: Chemes, Lucía B., et al.
Publicado: (2012)

SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence
por: Krainer, Georg, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a7mgpi11kh0bd41v9j0k2ha0k7