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Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

BACKGROUND: Pregnane X receptor (PXR) is a key transcription factor that regulates drug metabolizing enzymes such as cytochrome P450 (CYP) 3A4, and plays important roles in intestinal first-pass metabolism. Although there is a large inter-individual heterogeneity with intestinal CYP3A4 expression an...

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Detalles Bibliográficos
Autores principales:	Habano, Wataru, Gamo, Toshie, Terashima, Jun, Sugai, Tamotsu, Otsuka, Koki, Wakabayashi, Go, Ozawa, Shogo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053268/ https://www.ncbi.nlm.nih.gov/pubmed/21342487 http://dx.doi.org/10.1186/1471-2407-11-81

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