Causal Modeling Using Network Ensemble Simulations of Genetic and Gene Expression Data Predicts Genes Involved in Rheumatoid Arthritis

Tumor necrosis factor α (TNF-α) is a key regulator of inflammation and rheumatoid arthritis (RA). TNF-α blocker therapies can be very effective for a substantial number of patients, but fail to work in one third of patients who show no or minimal response. It is therefore necessary to discover new m...

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Detalles Bibliográficos
Autores principales: Xing, Heming, McDonagh, Paul D., Bienkowska, Jadwiga, Cashorali, Tanya, Runge, Karl, Miller, Robert E., DeCaprio, Dave, Church, Bruce, Roubenoff, Ronenn, Khalil, Iya G., Carulli, John
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053315/
https://www.ncbi.nlm.nih.gov/pubmed/21423713
http://dx.doi.org/10.1371/journal.pcbi.1001105

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