Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface

The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and...

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Autores principales: Kanellopoulos-Langevin, Colette, Caucheteux, Stéphane M, Verbeke, Philippe, Ojcius, David M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305337/
https://www.ncbi.nlm.nih.gov/pubmed/14651750
http://dx.doi.org/10.1186/1477-7827-1-121
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author Kanellopoulos-Langevin, Colette
Caucheteux, Stéphane M
Verbeke, Philippe
Ojcius, David M
author_facet Kanellopoulos-Langevin, Colette
Caucheteux, Stéphane M
Verbeke, Philippe
Ojcius, David M
author_sort Kanellopoulos-Langevin, Colette
collection PubMed
description The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.
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spelling pubmed-3053372004-01-01 Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface Kanellopoulos-Langevin, Colette Caucheteux, Stéphane M Verbeke, Philippe Ojcius, David M Reprod Biol Endocrinol Review The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise. BioMed Central 2003-12-02 /pmc/articles/PMC305337/ /pubmed/14651750 http://dx.doi.org/10.1186/1477-7827-1-121 Text en Copyright © 2003 Kanellopoulos-Langevin et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Review
Kanellopoulos-Langevin, Colette
Caucheteux, Stéphane M
Verbeke, Philippe
Ojcius, David M
Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
title Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
title_full Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
title_fullStr Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
title_full_unstemmed Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
title_short Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
title_sort tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305337/
https://www.ncbi.nlm.nih.gov/pubmed/14651750
http://dx.doi.org/10.1186/1477-7827-1-121
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AT verbekephilippe toleranceofthefetusbythematernalimmunesystemroleofinflammatorymediatorsatthefetomaternalinterface
AT ojciusdavidm toleranceofthefetusbythematernalimmunesystemroleofinflammatorymediatorsatthefetomaternalinterface

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