Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice

PURPOSE: Radiolabelled peptides used for peptide receptor radionuclide therapy are excreted mainly via the kidneys and are partly reabsorbed and retained in the proximal tubular cells. The resulting high renal radiation dose can cause nephrotoxicity, limiting the maximum activity dose and the effect...

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Detalles Bibliográficos
Autores principales: Vegt, Erik, Melis, Marleen, Eek, Annemarie, de Visser, Monique, Brom, Maarten, Oyen, Wim J. G., Gotthardt, Martin, de Jong, Marion, Boerman, Otto C.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053449/
https://www.ncbi.nlm.nih.gov/pubmed/21170526
http://dx.doi.org/10.1007/s00259-010-1685-9

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