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Molecular characterization of Korean rabies virus isolates

The nucleoprotein (N) and glycoprotein (G) of 11 Korean rabies virus (RABV) isolates collected from animals diagnosed with rabies between 2008 and 2009 were subjected to molecular and phylogenetic analyses. Six isolates originated from domestic animals (cattle and dogs) and five were obtained from w...

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Autores principales: Yang, Dong-Kun, Park, Young-Nam, Hong, Gyeong-Soo, Kang, Hee-Kyung, Oh, Yoon-I, Cho, Soo-Dong, Song, Jae-Young
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053468/
https://www.ncbi.nlm.nih.gov/pubmed/21368564
http://dx.doi.org/10.4142/jvs.2011.12.1.57
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author Yang, Dong-Kun
Park, Young-Nam
Hong, Gyeong-Soo
Kang, Hee-Kyung
Oh, Yoon-I
Cho, Soo-Dong
Song, Jae-Young
author_facet Yang, Dong-Kun
Park, Young-Nam
Hong, Gyeong-Soo
Kang, Hee-Kyung
Oh, Yoon-I
Cho, Soo-Dong
Song, Jae-Young
author_sort Yang, Dong-Kun
collection PubMed
description The nucleoprotein (N) and glycoprotein (G) of 11 Korean rabies virus (RABV) isolates collected from animals diagnosed with rabies between 2008 and 2009 were subjected to molecular and phylogenetic analyses. Six isolates originated from domestic animals (cattle and dogs) and five were obtained from wild free-ranging raccoon dogs. The similarities in the nucleotide sequences of the N gene among all Korean isolates ranged from 98.1 to 99.8%, while those of the G gene ranged from 97.9 to 99.3%. Based on the nucleotide analysis of the N and G genes, the Korean RABV isolates were confirmed as genotype I of Lyssavirus and classified into four distinct subgroups with high similarity. Phylogenetic analysis showed that the Korean isolates were most closely related to the non-Korean NeiMeng1025B and 857r strains, which were isolated from rabid raccoon dogs in Eastern China and Russia, respectively. These findings suggest that the Korean RABV isolates originated from a rabid raccoon dog in Northeastern Asia. Genetic analysis of the Korean RABV isolates revealed no substitutions at several antigenic sites, indicating that the isolates circulating in Korea may be pathogenic in several hosts.
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spelling pubmed-30534682011-03-22 Molecular characterization of Korean rabies virus isolates Yang, Dong-Kun Park, Young-Nam Hong, Gyeong-Soo Kang, Hee-Kyung Oh, Yoon-I Cho, Soo-Dong Song, Jae-Young J Vet Sci Original Article The nucleoprotein (N) and glycoprotein (G) of 11 Korean rabies virus (RABV) isolates collected from animals diagnosed with rabies between 2008 and 2009 were subjected to molecular and phylogenetic analyses. Six isolates originated from domestic animals (cattle and dogs) and five were obtained from wild free-ranging raccoon dogs. The similarities in the nucleotide sequences of the N gene among all Korean isolates ranged from 98.1 to 99.8%, while those of the G gene ranged from 97.9 to 99.3%. Based on the nucleotide analysis of the N and G genes, the Korean RABV isolates were confirmed as genotype I of Lyssavirus and classified into four distinct subgroups with high similarity. Phylogenetic analysis showed that the Korean isolates were most closely related to the non-Korean NeiMeng1025B and 857r strains, which were isolated from rabid raccoon dogs in Eastern China and Russia, respectively. These findings suggest that the Korean RABV isolates originated from a rabid raccoon dog in Northeastern Asia. Genetic analysis of the Korean RABV isolates revealed no substitutions at several antigenic sites, indicating that the isolates circulating in Korea may be pathogenic in several hosts. The Korean Society of Veterinary Science 2011-03 2011-03-05 /pmc/articles/PMC3053468/ /pubmed/21368564 http://dx.doi.org/10.4142/jvs.2011.12.1.57 Text en Copyright © 2011 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yang, Dong-Kun
Park, Young-Nam
Hong, Gyeong-Soo
Kang, Hee-Kyung
Oh, Yoon-I
Cho, Soo-Dong
Song, Jae-Young
Molecular characterization of Korean rabies virus isolates
title Molecular characterization of Korean rabies virus isolates
title_full Molecular characterization of Korean rabies virus isolates
title_fullStr Molecular characterization of Korean rabies virus isolates
title_full_unstemmed Molecular characterization of Korean rabies virus isolates
title_short Molecular characterization of Korean rabies virus isolates
title_sort molecular characterization of korean rabies virus isolates
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053468/
https://www.ncbi.nlm.nih.gov/pubmed/21368564
http://dx.doi.org/10.4142/jvs.2011.12.1.57
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