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Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study

BACKGROUND: The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. METHODS: Ecological study – investigating the relationship...

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Autores principales: Moll, Carina, Gessler, Ursula, Bartsch, Stephanie, El-sayeh, Hany George, Fenton, Mark, Adams, Clive Elliott
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305357/
https://www.ncbi.nlm.nih.gov/pubmed/14656379
http://dx.doi.org/10.1186/1471-244X-3-18
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author Moll, Carina
Gessler, Ursula
Bartsch, Stephanie
El-sayeh, Hany George
Fenton, Mark
Adams, Clive Elliott
author_facet Moll, Carina
Gessler, Ursula
Bartsch, Stephanie
El-sayeh, Hany George
Fenton, Mark
Adams, Clive Elliott
author_sort Moll, Carina
collection PubMed
description BACKGROUND: The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. METHODS: Ecological study – investigating the relationship between four economic/demographic variables and number of schizophrenia RCTs per country. The variable with closest correlation was used to predict the expected number of studies. RESULTS: GDP closely correlated with schizophrenia trial output, with 76% of the total variation about the Y explained by the regression line (r = 0.87, 95% CI 0.79 to 0.92, r2 = 0.76). Many countries have a strong tradition of schizophrenia trials, exceeding their predicted output. All nations with no identified trial output had GDPs that predicted zero trial activity. Several nations with relatively small GDPs are, nevertheless, highly productive of trials. Some wealthy countries seem either not to have produced the expected number of randomised trials or not to have disseminated them to the English-speaking world. CONCLUSIONS: This hypothesis-generating study could not investigate causal relationships, but suggests, that for those seeking all relevant studies, expending effort searching the scientific literature of Germany, Italy, France, Brazil and Japan may be a good investment.
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spelling pubmed-3053572004-01-01 Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study Moll, Carina Gessler, Ursula Bartsch, Stephanie El-sayeh, Hany George Fenton, Mark Adams, Clive Elliott BMC Psychiatry Research Article BACKGROUND: The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. METHODS: Ecological study – investigating the relationship between four economic/demographic variables and number of schizophrenia RCTs per country. The variable with closest correlation was used to predict the expected number of studies. RESULTS: GDP closely correlated with schizophrenia trial output, with 76% of the total variation about the Y explained by the regression line (r = 0.87, 95% CI 0.79 to 0.92, r2 = 0.76). Many countries have a strong tradition of schizophrenia trials, exceeding their predicted output. All nations with no identified trial output had GDPs that predicted zero trial activity. Several nations with relatively small GDPs are, nevertheless, highly productive of trials. Some wealthy countries seem either not to have produced the expected number of randomised trials or not to have disseminated them to the English-speaking world. CONCLUSIONS: This hypothesis-generating study could not investigate causal relationships, but suggests, that for those seeking all relevant studies, expending effort searching the scientific literature of Germany, Italy, France, Brazil and Japan may be a good investment. BioMed Central 2003-12-05 /pmc/articles/PMC305357/ /pubmed/14656379 http://dx.doi.org/10.1186/1471-244X-3-18 Text en Copyright © 2003 Moll et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Moll, Carina
Gessler, Ursula
Bartsch, Stephanie
El-sayeh, Hany George
Fenton, Mark
Adams, Clive Elliott
Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
title Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
title_full Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
title_fullStr Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
title_full_unstemmed Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
title_short Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
title_sort gross domestic product (gdp) and productivity of schizophrenia trials: an ecological study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305357/
https://www.ncbi.nlm.nih.gov/pubmed/14656379
http://dx.doi.org/10.1186/1471-244X-3-18
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