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Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study
BACKGROUND: The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. METHODS: Ecological study – investigating the relationship...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305357/ https://www.ncbi.nlm.nih.gov/pubmed/14656379 http://dx.doi.org/10.1186/1471-244X-3-18 |
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author | Moll, Carina Gessler, Ursula Bartsch, Stephanie El-sayeh, Hany George Fenton, Mark Adams, Clive Elliott |
author_facet | Moll, Carina Gessler, Ursula Bartsch, Stephanie El-sayeh, Hany George Fenton, Mark Adams, Clive Elliott |
author_sort | Moll, Carina |
collection | PubMed |
description | BACKGROUND: The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. METHODS: Ecological study – investigating the relationship between four economic/demographic variables and number of schizophrenia RCTs per country. The variable with closest correlation was used to predict the expected number of studies. RESULTS: GDP closely correlated with schizophrenia trial output, with 76% of the total variation about the Y explained by the regression line (r = 0.87, 95% CI 0.79 to 0.92, r2 = 0.76). Many countries have a strong tradition of schizophrenia trials, exceeding their predicted output. All nations with no identified trial output had GDPs that predicted zero trial activity. Several nations with relatively small GDPs are, nevertheless, highly productive of trials. Some wealthy countries seem either not to have produced the expected number of randomised trials or not to have disseminated them to the English-speaking world. CONCLUSIONS: This hypothesis-generating study could not investigate causal relationships, but suggests, that for those seeking all relevant studies, expending effort searching the scientific literature of Germany, Italy, France, Brazil and Japan may be a good investment. |
format | Text |
id | pubmed-305357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-3053572004-01-01 Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study Moll, Carina Gessler, Ursula Bartsch, Stephanie El-sayeh, Hany George Fenton, Mark Adams, Clive Elliott BMC Psychiatry Research Article BACKGROUND: The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. METHODS: Ecological study – investigating the relationship between four economic/demographic variables and number of schizophrenia RCTs per country. The variable with closest correlation was used to predict the expected number of studies. RESULTS: GDP closely correlated with schizophrenia trial output, with 76% of the total variation about the Y explained by the regression line (r = 0.87, 95% CI 0.79 to 0.92, r2 = 0.76). Many countries have a strong tradition of schizophrenia trials, exceeding their predicted output. All nations with no identified trial output had GDPs that predicted zero trial activity. Several nations with relatively small GDPs are, nevertheless, highly productive of trials. Some wealthy countries seem either not to have produced the expected number of randomised trials or not to have disseminated them to the English-speaking world. CONCLUSIONS: This hypothesis-generating study could not investigate causal relationships, but suggests, that for those seeking all relevant studies, expending effort searching the scientific literature of Germany, Italy, France, Brazil and Japan may be a good investment. BioMed Central 2003-12-05 /pmc/articles/PMC305357/ /pubmed/14656379 http://dx.doi.org/10.1186/1471-244X-3-18 Text en Copyright © 2003 Moll et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Article Moll, Carina Gessler, Ursula Bartsch, Stephanie El-sayeh, Hany George Fenton, Mark Adams, Clive Elliott Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study |
title | Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study |
title_full | Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study |
title_fullStr | Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study |
title_full_unstemmed | Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study |
title_short | Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study |
title_sort | gross domestic product (gdp) and productivity of schizophrenia trials: an ecological study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305357/ https://www.ncbi.nlm.nih.gov/pubmed/14656379 http://dx.doi.org/10.1186/1471-244X-3-18 |
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