Cargando…

A study on the effect of garlic to the heavy metal poisoning of rat.

When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages an...

Descripción completa

Detalles Bibliográficos
Autor principal: Cha, C. W.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053644/
https://www.ncbi.nlm.nih.gov/pubmed/3268178
_version_ 1782199776261963776
author Cha, C. W.
author_facet Cha, C. W.
author_sort Cha, C. W.
collection PubMed
description When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages and the inhibition of serum alkaline phosphatase activities by heavy metals were reduced. Such effect of garlic was not shown in the 1.7% garlic treated group and most remarkable in the 6.7% garlic treated group. The protective effect of garlic was superior to those of 2,3 dimercapto-1-propanol (BAL) and D-penicillamine (PEN), and nearly similar to those of 2,3-dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), the current remedies, while garlic was not effective as a curative agent for heavy metal poisoning. The excretion of cadmium was enhanced, more through feces than urine by garlic but the effect to the urinary excretion of cadmium was not significant comparing with DMSA or APEN when cadmium was ip injected in the first 3 days during the 12 days of oral administration of DMSA, APEN or garlic.
format Text
id pubmed-3053644
institution National Center for Biotechnology Information
language English
publishDate 1987
publisher Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-30536442011-03-16 A study on the effect of garlic to the heavy metal poisoning of rat. Cha, C. W. J Korean Med Sci Research Article When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages and the inhibition of serum alkaline phosphatase activities by heavy metals were reduced. Such effect of garlic was not shown in the 1.7% garlic treated group and most remarkable in the 6.7% garlic treated group. The protective effect of garlic was superior to those of 2,3 dimercapto-1-propanol (BAL) and D-penicillamine (PEN), and nearly similar to those of 2,3-dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), the current remedies, while garlic was not effective as a curative agent for heavy metal poisoning. The excretion of cadmium was enhanced, more through feces than urine by garlic but the effect to the urinary excretion of cadmium was not significant comparing with DMSA or APEN when cadmium was ip injected in the first 3 days during the 12 days of oral administration of DMSA, APEN or garlic. Korean Academy of Medical Sciences 1987-12 /pmc/articles/PMC3053644/ /pubmed/3268178 Text en
spellingShingle Research Article
Cha, C. W.
A study on the effect of garlic to the heavy metal poisoning of rat.
title A study on the effect of garlic to the heavy metal poisoning of rat.
title_full A study on the effect of garlic to the heavy metal poisoning of rat.
title_fullStr A study on the effect of garlic to the heavy metal poisoning of rat.
title_full_unstemmed A study on the effect of garlic to the heavy metal poisoning of rat.
title_short A study on the effect of garlic to the heavy metal poisoning of rat.
title_sort study on the effect of garlic to the heavy metal poisoning of rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053644/
https://www.ncbi.nlm.nih.gov/pubmed/3268178
work_keys_str_mv AT chacw astudyontheeffectofgarlictotheheavymetalpoisoningofrat
AT chacw studyontheeffectofgarlictotheheavymetalpoisoningofrat